Results 171 to 180 of about 689,327 (298)

Utilizing an Engineering Design-Based Research Approach to Study and Strengthen a Teacher Preparation Program in STEM at the Secondary Level (Work in Progress) [PDF]

Katherine Chen, Shari Weaver, Gretchen Fougere   +2 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Engineering bifidobacteria to deliver CRISPR antimicrobials targeting oncogenic <i>Fusobacterium nucleatum</i> in colorectal tumors. [PDF]

Ann Med Surg (Lond)
Mehmood MS, Qamar T, Amjad F, Danaf N.
europepmc   +1 more source

Preparation and characterization of Copper Chitosan Nanocomposites with Antibacterial Activity for Applications in Tissue Engineering

, 2015
K. Maldonado-Lara, Gabriel Luna‐Bárcenas, E. Luna-Hernández, F. Padilla-Vaca, E. Hernández-Sánchez, Rebeca Betancourt‐Galindo, Jorge Luis Menchaca, Beatriz Liliana España‐Sánchez, E. Hernández-Sánchez, Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, R. Betancourt-Galindo, Departamento de Materiales Avanzados, Centro de Investigación en Química Aplicada, J. L. Menchaca-Arredondo, Facultad de Ciencias Físico Matemáticas, Universidad Autónoma de Nuevo LeónKEYWORDS: Quitosano, Nanopartículas de cobre, Nanocompositos antibacterianos, B. L. España-Sánchez, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional   +15 more
openalex   +1 more source

Preparation and evaluation of biomimetric nano-hydroxyapatite-based composite scaffolds for bone-tissue engineering [PDF]

, 2012
Chunrong Yang, Yingjun Wang, Xiaofeng Chen   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Performance Optimization and Carbon Reduction Potential of Bamboo Biochar for Lightweight Artificial Aggregates. [PDF]

Materials (Basel)
Liu H, Bu L, Wang Y, Chen M, Chen D.
europepmc   +1 more source

Preparation and characterization of PCL polymeric scaffolds coated with chitosan/ bioactive glass/gelatin nanoparticles using the tips methodology for bone tissue engineering

, 2019
Gholamreza Savari Kozehkonan, Majid Salehi, Saeed Farzamfar, Hossein Ghanbari, Mehdi Adabi, Amir Amani   +5 more
openalex   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Automated assessment of small bowel and colon cleansing in enteroscopy using a convolutional neural network. [PDF]

Endosc Int Open
Marílio Cardoso P, Mascarenhas M, Martins M, Mendes F, Afonso J, Ribeiro T, Almeida MJ, Mota J, Andrade P, Cardoso H, Ferreira J, Macedo G.   +11 more
europepmc   +1 more source