Results 61 to 70 of about 2,073,600 (331)

Cold Matter Assembled Atom-by-Atom [PDF]

, 2016
The realization of large-scale fully controllable quantum systems is an exciting frontier in modern physical science. We use atom-by-atom assembly to implement a novel platform for the deterministic preparation of regular arrays of individually ...
Anschuetz, Eric R., Bernien, Hannes, Endres, Manuel, Greiner, Markus, Keesling, Alexander, Krajenbrink, Alexandre, Levine, Harry, Lukin, Mikhail D., Senko, Crystal, Vuletic, Vladan   +9 more
core   +2 more sources

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1

FEBS Letters, EarlyView.
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji, Kosuke Shiraishi, Chuqian Wang, Hiroya Yurimoto, Yasuyoshi Sakai, Masahide Oku   +5 more
wiley   +1 more source

Microglial double stranded DNA accumulation induced by DNase II deficiency drives neuroinflammation and neurodegeneration

Journal of Neuroinflammation
Background Deoxyribonuclease 2 (DNase II) is pivotal in the clearance of cytoplasmic double stranded DNA (dsDNA). Its deficiency incurs DNA accumulation in cytoplasm, which is a hallmark of multiple neurodegenerative diseases.
Ling-jie Li, Shi-yu Liang, Xiao-ying Sun, Jie Zhu, Xiao-yun Niu, Xiao-yu Du, Ya-ru Huang, Rui-tian Liu   +7 more
doaj   +1 more source

Research Progress on the Mechanism of Nanoparticles Crossing the Intestinal Epithelial Cell Membrane

Pharmaceutics, 2023
Improving the stability of drugs in the gastrointestinal tract and their penetration ability in the mucosal layer by implementing a nanoparticle delivery strategy is currently a research focus in the pharmaceutical field.
Yunjie He, Meng Cheng, Ruyue Yang, Haocheng Li, Zhiyang Lu, Yi Jin, Jianfang Feng, Liangxing Tu   +7 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Engineered microbial platform confers resistance against heavy metals via phosphomelanin biosynthesis

Nature Communications
Environmental concerns are increasingly fueling interest in engineered living materials derived from microbial sources. Melanin biosynthesis in microbes, particularly facilitated by recombinant tyrosinase expression, offers sustainable protection for the
Xiaokang Ren, Luyang Zhao, Jintao Shen, Peng Zhou, Kaili Zhao, Chengqian Yuan, Ruirui Xing, Xuehai Yan   +7 more
doaj   +1 more source

Anemoside B4 Rectal Thermosensitive In Situ Gel to Treat Ulcerative Colitis by Overcoming Oral Bioavailability Barriers with Absorption Enhancer-Assisted Delivery

Pharmaceutics
Background: Anemoside B4 (AB4), the major bioactive saponin from Pulsatilla chinensis, exhibits anti-inflammatory, anti-tumor, anti-apoptotic, and analgesic properties.
Xiaomeng Lei, Canjian Wang, Mingyan Xia, Guansheng Zhang, Tangxun Wang, Yang Chen, Yufang Huang, Tiantian Wang, Dongxun Li, Wenliu Zhang, Guosong Zhang   +10 more
doaj   +1 more source

Microstructure Design of High-Entropy Alloys Through a Multistage Mechanical Alloying Strategy for Temperature-Stable Megahertz Electromagnetic Absorption

Nano-Micro Letters, 2022
Developing megahertz (MHz) electromagnetic wave (EMW) absorption materials with broadband absorption, multi-temperature adaptability, and facile preparation method remains a challenge.
Xiaoji Liu, Yuping Duan, Yuan Guo, Huifang Pang, Zerui Li, Xingyang Sun, Tongmin Wang   +6 more
doaj   +1 more source

Achieving equity through 'gender autonomy': the challenges for VET policy and practice [PDF]

, 2006
This paper is based on research carried out in an EU Fifth Framework project on 'Gender and Qualification'. The research partners from five European countries investigated the impact of gender segregation in European labour markets on vocational ...
Bates I., Brine J., Cameron C., Cockburn C., Connell R. W., Evans K., Faulkner W., Heidegger G., Heikkinen A., Heikkinen A., Hoffmann B., Hoffmann B., Kampmeier A., Karen Evans, Kleinan E., Newton P., Niemeyer B., Nijhof W. J., Nijhof W. J., Noon M., Roth H., Singh R., Skeggs B., Williams C.   +23 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source