Results 61 to 70 of about 2,141,178 (305)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Preparation and Characterization of Chitooligosaccharide–Polylactide Polymers, and In Vitro Release of Microspheres Loaded with Vancomycin

Journal of Functional Biomaterials, 2022
Drug-loaded microspheres are an ideal bone tissue delivery material. In this study, a biodegradable Schiff base chitosan–polylactide was used as the encapsulation material to prepare drug-loaded microspheres as biocompatible carriers for controlled ...
Jiaxin Li, Ruimin Tang, Penghao Zhang, Minglong Yuan, Hongli Li, Mingwei Yuan   +5 more
doaj   +1 more source

Preparing the bound instance of quantum entanglement

, 2011
Among the possibly most intriguing aspects of quantum entanglement is that it comes in "free" and "bound" instances. Bound entangled states require entangled states in preparation but, once realized, no free entanglement and therefore no pure maximally ...
DiGuglielmo, J., Eisert, J., Hage, B., Pineda, C., Samblowski, A., Schnabel, R.   +5 more
core   +1 more source

Beyond 2020: Preparing Engineers for the Future

Proceedings of the IEEE, 2012
Over the past 20 years, the world has seen significant advances in and adoption of new technology, political events that have led to the opening of formerly closed societies, economic policies that have encouraged free trade, and the growth in multinational companies.
openaire   +1 more source

Preparing Design Engineers For The Future [PDF]

2001 Annual Conference Proceedings, 2020
The Partnership for the Advancement of CAD/CAM/CAE Education (PACE) is an alliance between General Motors, EDS, Unigraphics Solutions, and Sun Microsystems. Its mission is to integrate math-based, three-dimensional solid modeling—using Unigraphics—into the engineering and design curricula of strategically selected academic institutions worldwide.
Tony Brune, Elaine Chapman-Moore, Dave Wiese, Hulas King   +3 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Microglial double stranded DNA accumulation induced by DNase II deficiency drives neuroinflammation and neurodegeneration

Journal of Neuroinflammation
Background Deoxyribonuclease 2 (DNase II) is pivotal in the clearance of cytoplasmic double stranded DNA (dsDNA). Its deficiency incurs DNA accumulation in cytoplasm, which is a hallmark of multiple neurodegenerative diseases.
Ling-jie Li, Shi-yu Liang, Xiao-ying Sun, Jie Zhu, Xiao-yun Niu, Xiao-yu Du, Ya-ru Huang, Rui-tian Liu   +7 more
doaj   +1 more source

Anemoside B4 Rectal Thermosensitive In Situ Gel to Treat Ulcerative Colitis by Overcoming Oral Bioavailability Barriers with Absorption Enhancer-Assisted Delivery

Pharmaceutics
Background: Anemoside B4 (AB4), the major bioactive saponin from Pulsatilla chinensis, exhibits anti-inflammatory, anti-tumor, anti-apoptotic, and analgesic properties.
Xiaomeng Lei, Canjian Wang, Mingyan Xia, Guansheng Zhang, Tangxun Wang, Yang Chen, Yufang Huang, Tiantian Wang, Dongxun Li, Wenliu Zhang, Guosong Zhang   +10 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Engineered microbial platform confers resistance against heavy metals via phosphomelanin biosynthesis

Nature Communications
Environmental concerns are increasingly fueling interest in engineered living materials derived from microbial sources. Melanin biosynthesis in microbes, particularly facilitated by recombinant tyrosinase expression, offers sustainable protection for the
Xiaokang Ren, Luyang Zhao, Jintao Shen, Peng Zhou, Kaili Zhao, Chengqian Yuan, Ruirui Xing, Xuehai Yan   +7 more
doaj   +1 more source