Results 11 to 20 of about 8,407 (184)

Drainage of Small Volume Reservoirs on the Technogenic Territories

MATEC Web of Conferences, 2018
The development of residential construction on alluvial territories requires high-quality engineering background in the initial stages of development. In the area with high ground moisture, the erection of buildings is difficult and drainage measures are
Davydova Yana, Volkova Yulia, Nikonorov Aleksandr, Aleksandrovskiy Maksim   +3 more
doaj   +1 more source

HYDRAULIC ASPECTS OF LOGJAM FORMATION DURING EXTREME HIGH FLOODS

Водное хозяйство России: проблемы, технологии, управление, 2020
The article discusses the mechanisms of formation of congestion of trees in front of the bridge during high floods that can significantly increase the water level in the pre-bridge zone.
Andrey P. Lepikhin, Anna A. Wozniak
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Activity-based organization of extracurricular work as a condition for competency development in future history teachers in Kazakhstan

Frontiers in Education
BackgroundTraining modern history teachers is a complex process that must continuously account for shifts in social life, new pedagogical concepts, multiple interpretations of historical events, and the conservatism of academic traditions.
Dinara Satkey, Amanbek Narkoziev
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Conceptual model of post-war restoration of agricultural land with integration of bioenergy technologies

Наукові доповіді Національного університету біоресурсів і природокористування України
Russia’s full-scale military actions against Ukraine led to large-scale degradation of agricultural land, which was accompanied by mechanical destruction of soil cover, chemical pollution, and loss of productive potential.
T. Chaika, M. Shevnikov, A. Stetsenko, V. Liashenko   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source