Results 131 to 140 of about 1,590,550 (317)
Water for Life: A Journey to Nicaragua Exploring Sustainable Development [PDF]
, 2009 When I first arrived in the Peruvian Altiplano as a Maryknoll missioner 15 years ago, I was struck by the presence of a beautifully engineered system of irrigation canals extending through several communities. Engineers love to solve problems, and seeing
Maurer, Edwin P.
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Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Assessment of work-based reports: an analysis of assessment frameworks [PDF]
, 2005 In Britain engineering professional development has traditionally been seen as a three phase process consisting of a period of engineering formation, a period of training and a period during which engineering responsibilities are demonstrated.
Monk, John
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Men, Masculinities and Water Powers in Irrigation
Water Alternatives, 2008 The aim of this article is to provide an informed plea for more explicitly identifying, naming and unravelling the linkages between water control and gender in irrigation.
Margreet Zwarteveen
doaj
Industrial engineering in Spain, the challenge of a new liberal profession in the nineteenth century [PDF]
, 2014 Industrial engineering was established in Spain in 1850. Despite the initial difficulties, the profession found its role in the process of the industrialization of Spain.
Roca Rosell, Antoni Maria Claret
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Differential migration prospects, skill formation, and welfare [PDF]
This paper develops a one sector, two-input model with endogenous human capital formation. The two inputs are two types of skilled labor: engineering, which exerts a positive externality on total factor productivity, and law, which does not.
Stark, Oded, Zakharenko, Roman
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