Results 131 to 140 of about 1,596,446 (317)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Differential migration prospects, skill formation, and welfare [PDF]
This paper develops a one sector, two-input model with endogenous human capital formation. The two inputs are two types of skilled labor: engineering, which exerts a positive externality on total factor productivity, and law, which does not.
Stark, Oded, Zakharenko, Roman
core
Application of Advanced Early Warning Systems with Adaptive Protection [PDF]
, 2015 This project developed and field-tested two methods of Adaptive Protection systems utilizing synchrophasor data. One method detects conditions of system stress that can lead to unintended relay operation, and initiates a supervisory signal to modify ...
Ashrafi, Frank +7 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
USAbroadThis article deals with the nautical charts of the Great Lakes, made by the U.S. Army Corps of Engineers in the second half of the 19th century. It explores the role of these documents in the capitalist transformation of this risky border region from ...
Rémi Boucay
doaj +1 more source
NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 13: The information-seeking habits and practices of engineers [PDF]
It is argued that only by maximizing the research and development process can the United States maintain and possibly capture its international competitive edge.
Pinelli, Thomas E.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Men, Masculinities and Water Powers in Irrigation
Water Alternatives, 2008 The aim of this article is to provide an informed plea for more explicitly identifying, naming and unravelling the linkages between water control and gender in irrigation.
Margreet Zwarteveen
doaj
Industrial engineering in Spain, the challenge of a new liberal profession in the nineteenth century [PDF]
, 2014 Industrial engineering was established in Spain in 1850. Despite the initial difficulties, the profession found its role in the process of the industrialization of Spain.
Roca Rosell, Antoni Maria Claret
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source