Results 121 to 130 of about 1,080,903 (314)

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

open access: yesAdvanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin   +9 more
wiley   +1 more source

New England Lyme Disease in England

open access: yesPediatric Neurology Briefs, 1987
A 6 year old boy seen this month after recovery from severe neurological complications of Lyme disease prompts this report to alert pediatricians and neurologists to the increase in incidence of this seasonal infectious disease, especially among campers in the United States, Europe, and Australia.
openaire   +3 more sources

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

open access: yesAdvanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao   +17 more
wiley   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang   +9 more
wiley   +1 more source

A Two‐Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto‐Aerotaxis

open access: yesAdvanced Science, EarlyView.
Magnetotactic bacteria align with Earth's magnetic field, helping them migrate toward low‐oxygen environments. This study reveals how Magnetospirillum gryphiswaldense uses a specialized flavin adenine dinucleotide (FAD)‐dependent chemoreceptor, composed of two interacting proteins, for precise navigation in oxygen gradients.
Julian Herz   +13 more
wiley   +1 more source

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