Results 151 to 160 of about 1,080,903 (314)

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

The challenges of replication: A worked example of methods reproducibility using electronic health record data. [PDF]

PLoS One
Williams R, Bolton T, Jenkins D, Mizani MA, Sperrin M, Sudlow C, Wood A, Heald A, Peek N, CVD-COVID-UK/COVID-IMPACT Consortium.   +9 more
europepmc   +1 more source

A List of the Orthoptera of New England [PDF]

, 1900
Samuel H. Scudder
openalex   +1 more source

Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine

Advanced Science, EarlyView.
A glucose‐catalyzed chemodynamic strategy is proposed to activate therapeutic genome editing of SMARCAL1to improve cancer immunotherapy. This innovative design featuring Fenton reaction activity and glucose consumption ability, not only effectively synergizes to activate the cGAS‐STING pathway but also inhibits the opposing functions of interferon by ...
Yuwei Li, Yuanyi Zhang, Chenchen Li, Guoping Chen, Pir Muhammad, Yonghong Yao, Lifang Gao, Zhigang Liu, Yanli Wang   +8 more
wiley   +1 more source

Variation in duration of repeat prescriptions: a primary care cohort study in England. [PDF]

Br J Gen Pract
MacKenna B, Brown AD, Croker R, Walker AJ, Goldacre B, Tsiachristas A, Evans D, Inglesby P, Bacon S, Curtis HJ.   +9 more
europepmc   +1 more source

Descriptive and Illustrated Catalogue of the Physiological Series of Comparative Anatomy contained in the Museum of the Royal College of Surgeons of England

, 1900

openalex   +2 more sources

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

Advanced Science, EarlyView.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado, Samuel Vicente‐Gil, Esther Morel, Pablo Jiménez‐Barrios, Rocío Simón, Pedro Perdiguero, Diana Martín, Marta Vargas‐Ramírez, Niels Lorenzen, Jacob Günther Schmidt, Carolina Tafalla   +10 more
wiley   +1 more source

AI‐Driven Defecation Analysis by Smart Healthcare Toilet: Exploring Biometric Patterns and Eu‐Tenesmus

Advanced Science, EarlyView.
A healthcare toilet system is introduced to passively measure defecation behavior. Real‐time data on stool dropping duration, thickness, and a newly defined “eu‐tenesmus” interval show correlations with stool form and gender differences. Results from 45 defecation events reveal a promising method for comprehensive defecation analysis.
Zhiquan Song, TaeHyung Kwon, Jeung Lee, Daeyoun D. Won, Brian J. Lee, Hyuk Soon Choi, Joseph C. Liao, Walter G. Park, Irene Sonu, Stephan Rogalla, Michael J. Rosen, David L. Hu, Jonathan Kuang Ziyang, Sunny Hei Wong, Bong Hyun Jun, Soh Kim, Seung‐min Park   +16 more
wiley   +1 more source

Sickness absence rates in NHS England staff during the COVID-19 pandemic: Insights from multivariate regression and time series modelling. [PDF]

PLoS One
McTaggart E, Megiddo I, Bowers J, Kleczkowski A.   +3 more
europepmc   +1 more source

Lectures on the Industrial Revolution of the Eighteenth Century in England; Popular Addresses, Notes and other Fragments.

, 1908
F. C. Montague, Arnold J. Toynbee, Lord Milner   +2 more
openalex   +2 more sources