Results 271 to 280 of about 4,724,242 (392)

A Pan‐TE Map Reveals the Important Role of Transposable Elements in Gene Expression and Phenotypic Diversity in 2,311 Rapeseed Accessions

Advanced Science, EarlyView.
This study presents the first pan‐transposable element (TE) atlas in rapeseed, profiling over 8 million TEs across 2311 accessions. Integrative analyses reveal that TEs broadly shape gene expression through diverse regulatory mechanisms, with key insertions in BnaA03.FLC and BnaA09.CYP78A9 linked to flowering time and silique development.
Zhiquan Yang, Haiyan Fan, Yifan Chen, Jiawei Li, Minjian Chen, Yingying Tan, Liang Guo, Jintao Li, Kede Liu, Qing‐Yong Yang   +9 more
wiley   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Correction: All-Cause Mortality of Low Birthweight Infants in Infancy, Childhood, and Adolescence: Population Study of England and Wales

, 2016
The PLOS Medicine Staff
openalex   +2 more sources

Patterns of regional variation of opioid prescribing in primary care in England: a retrospective observational study.

The British journal of general practice : the journal of the Royal College of General Practitioners, 2018
L. Mordecai, Carl H Reynolds, L. Donaldson, A. C. de C Williams   +3 more
semanticscholar   +1 more source

RNA G‐Quadruplex RIBOTAC‐Mediated Targeted Degradation of lncRNA TERRA

Advanced Science, EarlyView.
This study introduces a selective RNA degradation strategy targeting long noncoding RNA (lncRNA) TERRA, upregulated in ALT (alternative lengthening of telomeres) cancer cells. Using ribonuclease‐targeting chimeras (RIBOTACs), RNase L is recruited to catalytically degrade TERRA, uncovering a novel approach to affect a disease associated lncRNA in ALT ...
Elias Khaskia, Dipak Dahatonde, Raphael I. Benhamou   +2 more
wiley   +1 more source

Decision-making for termination of pregnancy following non-invasive prenatal testing: a qualitative exploration of french, english and German healthcare professionals' perceptions and concerns. [PDF]

Reprod Health
Perrot A, Bowman-Smart H, Nov-Klaiman T, Horn R.   +3 more
europepmc   +1 more source

Marginal Stability of the YB1 Cold‐Shock Domain in Cells Enables Binding of Multiple Nucleic Acids

Advanced Science, EarlyView.
This study suggests that the marginal stability of the YB1 Cold‐Shock Domain (CSDex) allows for a balance between multifunctionality and conformational changes under physiological conditions. This balance is driven by the dynamic equilibrium between the unfolded ensemble (UE) and the native ensemble (NE) of CSDex (PDB:6LMR).
Puja Shrestha, Sara S. Ribeiro, Janne Aurich, Christian Herrmann, Simon Ebbinghaus   +4 more
wiley   +1 more source

Lifestyle psychiatry: a conceptual framework for application in mental healthcare and support. [PDF]

BMJ Ment Health
Deenik J, Vermeulen JM, Teasdale SB, Schuch FB, Marx W, Perry B, Diez GG, Castellanos N, Elshazly M, Gatera G, Waugh M, Hepsomali P, Bueno-Antequera J, Borrueco Sánchez J, Lopez Moral A, López-Sánchez C, Oviedo Caro MA, Dejonge M, Noortman C, van Schothorst M, den Bleijker N, Scrivano L, Noordsy DL, Fabian H, Jachyra P, Chapman J, Merlo G, Manger S, O'Neil A, Machaczek KK, Ardill-Young O, Ramírez P, Matthews E, Lambert J, Firth J, Hassan L, Jacka FN, Ward P, Stubbs B, Cahn W, Rosenbaum S, Vancampfort D, Firth J.   +42 more
europepmc   +1 more source

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

Teachers' experiences of delivering youth vaping prevention materials in schools in England and Scotland: A cross-sectional online survey. [PDF]

PLoS One
Lee A, Walsh H, Nottage M, Fincham-Campbell S, Taylor E, Robson D, Conner M, East K.   +7 more
europepmc   +1 more source