Results 41 to 50 of about 4,282,224 (344)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Intravenous infusion practices across England and their impact on patient safety: a mixed-methods observational study

Health Services and Delivery Research, 2020
Background: Intravenous (IV) medication administration has traditionally been regarded to be error-prone with high potential for harm. A recent US multisite study revealed surprisingly few potentially harmful errors despite a high overall error rate ...
Ann Blandford, Dominic Furniss, Galal H Galal-Edeen, Gill Chumbley, Li Wei, Astrid Mayer, Bryony Dean Franklin   +6 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Womersley, James II: The Last Catholic King (Penguin, 2015)

Royal Studies Journal, 2017
Review of David Womersley, James II: The Last Catholic King (London: Penguin, 2015).
Hannah Jane Thomas
doaj   +1 more source

The Long-Term Impacts of an Integrated Care Programme on Hospital Utilisation among Older Adults in the South of England: A Synthetic Control Study

International Journal of Integrated Care, 2023
Introduction: Reducing hospital use is often viewed as a possible positive consequence of introducing integrated care (IC). We investigated the impact of an IC programme in North East Hampshire and Farnham (NEHF), in southern England, on hospital ...
Paul Seamer, Therese Lloyd, Stefano Conti, Stephen O’Neill   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Using the politicized institutional analysis and development framework to analyze (adaptive) comanagement: farming and water resources in England

Ecology and Society, 2015
The challenge of managing water resources in England is becoming increasingly complex and uncertain, a situation reflected in many countries around the world.
Luke Whaley, Edward K. Weatherhead
doaj   +1 more source

Analysis of the functions of English Orientalism in Balochistan (the nineteenth and first half of the twentieth century) [PDF]

پژوهش‌های تاریخی ایران و اسلام, 2018
Eastern Studies is a collection of studies and researches of scientists and institutions of the Western countries on various issues of the Orient.
reza bigdelou, Ahmad abou hamzeh
doaj   +1 more source

Definition of puritanism and its interpretations

Российский журнал истории Церкви, 2023
The article deals with the appearance in the context of the development of the English Reformation in the middle of the 16th century of supporters of the further reformation of the Church of England following the example of the European continental ...
V. N. Yerokhin
doaj   +1 more source

Remote hearings in family courts in England and Wales during Covid‐19: Insights and lessons [PDF]

, 2022
Lisa Harker, Mary P. Ryan
openalex   +1 more source