Results 41 to 50 of about 923,186 (267)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Intravenous infusion practices across England and their impact on patient safety: a mixed-methods observational study

Health Services and Delivery Research, 2020
Background: Intravenous (IV) medication administration has traditionally been regarded to be error-prone with high potential for harm. A recent US multisite study revealed surprisingly few potentially harmful errors despite a high overall error rate ...
Ann Blandford, Dominic Furniss, Galal H Galal-Edeen, Gill Chumbley, Li Wei, Astrid Mayer, Bryony Dean Franklin   +6 more
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Trends in Hospital Admission Due to Diseases of the Eye and Adnexa in the Past Two Decades in England and Wales: An Ecological Study

International Journal of General Medicine, 2022
Hamzeh Mohammad Alrawashdeh,1,* Abdallah Y Naser,2,* Hassan Alwafi,3,4 Amal Khaleel AbuAlhommos,5 Zahra Jalal,6 Vibhu Paudyal,6 Dina M Abdulmannan,3 Fadi Fouad Hassanin,7 Sara Ibrahim Hemmo,2 Fawaz Al Sarireh8 1Department of Ophthalmology, Sharif
Alrawashdeh HM, Naser AY, Alwafi H, AbuAlhommos AK, Jalal Z, Paudyal V, Abdulmannan DM, Hassanin FF, Hemmo SI, Al Sarireh F   +9 more
doaj  

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Residential child care in England

Scottish Journal of Residential Child Care, 2016
This article provides a summary of the current context for residential child care in England. It records continually increasing outcomes as evidenced in a new set of Quality Standards by a new inspection framework.
Jonathan Stanley
doaj   +1 more source

FOREIGN LOAN POLICY OF PAUL I

Вестник Кемеровского государственного университета, 2017
This article analyzes the development of the external state debt of the Russian Empire during the reign of Paul I. That period was marked by dynamic processes in Russia's foreign policy in general and in the development of its foreign debt in particular.
Oleg V. Baev
doaj   +1 more source

A new pliosaurid from the Oxford Clay Formation of Oxfordshire, UK

Acta Palaeontologica Polonica, 2022
We describe the anatomy of a new longirostrine pliosaurid, Eardasaurus powelli gen. et sp. nov., based on a substantially complete skeleton from the Middle Jurassic Oxford Clay Formation of Oxfordshire, UK.
HILARY F. KETCHUM, ROGER B.J. BENSON
doaj   +1 more source