Results 81 to 90 of about 4,724,242 (392)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

The English Origins of Geotourism (as a Vehicle for Geoconservation) and Their Relevance to Current Studies

Acta Geographica Slovenica, 2011
This paper contextualises the recognition of the geotourism concept. It stresses the underpinning geoconservation purpose that drove its development in England. It notes the multidisciplinary nature of geotourism research.
Thomas A. Hose
doaj   +1 more source

Assessment in vocational programmes in the further education sector in England: report from the Inspectorate (National survey report, January 1995) [PDF]

, 1995
This national survey report is concerned with the assessment of students attending all types of vocational education and training programmes offered by further education sector colleges in England.

core  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

The costs of dementia in England

International Journal of Geriatric Psychiatry, 2019
This study measures the average per person and annual total costs of dementia in England in 2015.
R. Wittenberg, M. Knapp, B. Hu, A. Comas-Herrera, D. King, A. Rehill, Cheng Shi, Sube Banerjee, Anita Patel, C. Jagger, A. Kingston   +10 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Queen Victoria and The Royal Disease [PDF]

, 2018
Queen Victoria, Queen of England and Ireland and Empress of India, is the second longest ruling monarch of England, she sat on the throne for sixty –three years and was so crucial to the formation of England that there is a whole era names after her, The
Mullen, Madeline
core   +1 more source

Impacts of neonicotinoid use on long-term population changes in wild bees in England

Nature Communications, 2016
Wild bee declines have been ascribed in part to neonicotinoid insecticides. While short-term laboratory studies on commercially bred species (principally honeybees and bumblebees) have identified sub-lethal effects, there is no strong evidence linking ...
B. Woodcock, Nick J. B. Isaac, James M. Bullock, D. Roy, Dave Garthwaite, Andrew Crowe, R. Pywell   +6 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Womersley, James II: The Last Catholic King (Penguin, 2015)

Royal Studies Journal, 2017
Review of David Womersley, James II: The Last Catholic King (London: Penguin, 2015).
Hannah Jane Thomas
doaj   +1 more source