Results 81 to 90 of about 4,806,683 (407)

Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study

Lancet. Infectious Diseases (Print), 2020
Summary Background A second wave of COVID-19 cases in autumn, 2020, in England led to localised, tiered restrictions (so-called alert levels) and, subsequently, a second national lockdown.
N. Davies, R. Barnard, C. Jarvis, T. Russell, M. Semple, M. Jit, W. J. Edmunds   +6 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Data Resource Profile: National Cancer Registration Dataset in England

International Journal of Epidemiology, 2019
The National Cancer Registration and Analysis Service (NCRAS), part of Public Health England (PHE), is the population-based cancer registry for England. It collects, quality assures and analyses data on all people living in England who are diagnosed with
Katherine E Henson, L. Elliss-Brookes, Victoria H. Coupland, E. Payne, S. Vernon, B. Rous, J. Rashbass   +6 more
semanticscholar   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Trends in Hospital Admission Due to Diseases of the Eye and Adnexa in the Past Two Decades in England and Wales: An Ecological Study

International Journal of General Medicine, 2022
Hamzeh Mohammad Alrawashdeh,1,* Abdallah Y Naser,2,* Hassan Alwafi,3,4 Amal Khaleel AbuAlhommos,5 Zahra Jalal,6 Vibhu Paudyal,6 Dina M Abdulmannan,3 Fadi Fouad Hassanin,7 Sara Ibrahim Hemmo,2 Fawaz Al Sarireh8 1Department of Ophthalmology, Sharif
Alrawashdeh HM, Naser AY, Alwafi H, AbuAlhommos AK, Jalal Z, Paudyal V, Abdulmannan DM, Hassanin FF, Hemmo SI, Al Sarireh F   +9 more
doaj  

Intravenous infusion practices across England and their impact on patient safety: a mixed-methods observational study

Health Services and Delivery Research, 2020
Background: Intravenous (IV) medication administration has traditionally been regarded to be error-prone with high potential for harm. A recent US multisite study revealed surprisingly few potentially harmful errors despite a high overall error rate ...
Ann Blandford, Dominic Furniss, Galal H Galal-Edeen, Gill Chumbley, Li Wei, Astrid Mayer, Bryony Dean Franklin   +6 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Residential child care in England

Scottish Journal of Residential Child Care, 2016
This article provides a summary of the current context for residential child care in England. It records continually increasing outcomes as evidenced in a new set of Quality Standards by a new inspection framework.
Jonathan Stanley
doaj   +1 more source