Results 121 to 130 of about 11,262,937 (341)
Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA
Advanced Science, EarlyView.In this study, a chemically engineered zwitterionic phospholipids derived from 1,2‐dioleoyl‐3‐sn‐glycero‐phosphoethanolamine (DOPE), DOPE‐Cx, are designed. The DOPE‐Cx lipids induce a cubic phase upon mixing with phosphatidylcholine, facilitate membrane fusion‐mediated endosomal escape, and enhance the functional delivery of mRNA.
Kazuki Iwakawa +5 more
wiley +1 more source
Advanced Science, EarlyView.Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du +8 more
wiley +1 more source
Advanced Science, EarlyView.Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu +10 more
wiley +1 more source
Vermicular Eutectic Multi‐Principal Element Alloy with Exceptional Strength and Ductility
Advanced Science, EarlyView.Eutectic multi‐principal element alloys (EMPEAs) typically exhibit rod‐like or lamellar microstructures, constraining further mechanical improvements. This study introduces a novel (AlCrFe2)65Ni35 EMPEA with a unique vermicular microstructure, achieving unprecedented strength‐ductility synergy.
Liufei Huang +11 more
wiley +1 more source
Piezoresistive Effect: A New Concept for Hearing Aids
Advanced Science, EarlyView.An MXene/PVA sound sensor utilizing piezoresistive effects has been proposed with a detection limit of 60 dB and a frequency response of 20–4000 Hz, which is comparable to the performance of commercial hearing aids. By combining the sensor with machine learning, the accuracy rate of voiceprint recognition of wildlife conservation can reach up to 99 ...
Mengyao Gao +8 more
wiley +1 more source
Malaysian English News Decoded: A Linguistic Resource for Named Entity and Relation Extraction [PDF]
arXivStandard English and Malaysian English exhibit notable differences, posing challenges for natural language processing (NLP) tasks on Malaysian English. Unfortunately, most of the existing datasets are mainly based on standard English and therefore inadequate for improving NLP tasks in Malaysian English. An experiment using state-of-the-art Named Entity
arxiv
Advanced Energy and Sustainability Research, EarlyView.Mineral carbonation using seawater for CO2 utilization under a magnesium‐based system versus a calcium‐based system with low energy input is investigated. The reaction mechanism, kinetics, and insights into reaction optimization are provided. This study can serve as a reference for developing mineral carbonation using seawater with application of ...
Hsing‐Jung Ho, Atsushi Iizuka
wiley +1 more source
Which English is English? [PDF]
International Journal of Epidemiology, 2018 openaire +5 more sources
American Journal of Community Psychology, Volume 70, Issue 3-4, Page 327-339, December 2022., 2022 Abstract The capabilities approach offers a multidimensional, ecological, and agent‐centered framework that may inspire models of intervention and evaluation. A growing number of measures grounded on the capabilities approach for outcome measurement are appearing.
Beatrice Sacchetto +2 more
wiley +1 more source