Results 51 to 60 of about 146,544 (286)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Randomized clinical trial of the effect of glucocorticoids on peritoneal inflammation and postoperative recovery after colectomy

, 2009
Background: Recent data have Suggested a relationship between Postoperative fatigue and the peritoneal cytokine response after surgery. The aim of this study was to test the hypothesis that preoperative administration of glucocorticoids before surgery ...
Connolly, AB, Zargar Shoshtari, Kamran, K Zargar-Shoshtari, Hill, Andrew, Sammour, T, A G Hill, Kahokehr, A, T Sammour, A B Connolly, A Kahokehr   +9 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Revolutionizing perioperative medicine: Technological advancements for enhanced recovery [PDF]

Serbian Journal of Anesthesia and Intensive Therapy
Enhanced Recovery After Surgery (ERAS) is a multimodal, evidence-based approach designed to minimize surgical stress, accelerate recovery, and improve patient outcomes.
Bharadwaj Abhishek
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Effects of Implementing an Enhanced Recovery after Surgery pathway on Hysterectomy Postoperative Outcomes [PDF]

Egyptian Journal of Health Care
Background: The implementation of an Enhanced Recovery after Surgery (ERAS) pathway for women undergoing hysterectomy represents a rigorously evidence-based strategy aimed at improving postoperative outcomes, mitigating complications, facilitating ...
Nehal Shalaby Awad Mahmoud, Hanan Abdelrahman Mostafa Kandeel, Samar Elrefaey Elrefaey Abaza   +2 more
doaj   +1 more source

The benefits of enhanced recovery after surgery

Journal of Visceral Surgery, 2016
Enhanced recovery programs (ERP) after surgery are now being increasingly applied in daily practice. The purpose of this article is to review specific aspects and advantages of this approach. Beyond the reduction in overall morbidity (found for multiple surgical specialties), ERP include issues and stakes that affect patient care, the care team and ...
openaire   +2 more sources

Enhanced recovery after surgery programs hasten recovery after colorectal resections

, 2011
Colorectal resection was traditionally associated with significant morbidity and prolonged stay in hospital. Laparoscopic colorectal resection was first described in 1991 as a minimally invasive form of colorectal surgery.
Albayati, Sinan, Abraham, N
core   +1 more source

Assessment of chronic postsurgical pain after knee replacement : a systematic review [PDF]

, 2013
Objective: Approximately 20% of patients experience chronic pain after total knee replacement (TKR), yet there is no consensus about how best to assess such pain.
Rachael Gooberman‐Hill, Karen Elvers, Vikki Wylde, Wylde, Vikki, Beswick, Andrew, Elvers, Karen, Julie Bruce, Gooberman-Hill, Rachael, Bruce, Julie, Andrew Beswick, Bruce, J. (Julie)   +10 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source