Results 71 to 80 of about 5,318,618 (294)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Air-Side Heat Transfer Performance of Louver Fin and Multi-Tube Heat Exchanger for Fuel-Cell Cooling Application [PDF]
, 2012 The present work is performed to evaluate the heat transfer performance of a heat exchanger used in a fuel cell. Because of material constraints and performance requirements, a louver fin heat exchanger is modified for use with conventional micro-channel
Jacobi, Anthony M. +4 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Slide Valves for Single-Screw Expanders Working Under Varied Operating Conditions
Energies, 2016 This paper fully describes the working principle of slide valves in single-screw expanders (SSEs). A geometric analysis of suction and volume ratio slide valves is presented to determine the relations between volume ratio, suction closure volume ...
Yuting Wu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanism and behavior of nucleate boiling heat transfer to the alkalai liquid metals [PDF]
, 1969 A model of boiling heat transfer to the alkali liquid metals is postulated from an examination of the events and phases of the nucleate boiling cycle. The model includes the important effect of microlayer evaporation which causes a wave of temperature ...
Deane, Charles William +1 more
core
Applied Sciences, 2019 The organic Rankine cycle (ORC) is a popular technology used in waste heat recovery and low-grade heat utilization, which are two important measures to solve the problems brought by the energy crisis.
Xinxin Zhang +4 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Experimental Study on Heat Loss of a Single Screw Expander for an Organic Rankine Cycle System
Frontiers in Energy Research, 2020 For displacement expanders, the irreversible losses include leakage, friction, heat dissipation, and flow resistance. Currently, the research on the heat loss of expanders is scarce, especially with regards to experimental studies.
Wei Wang +9 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source