Results 71 to 80 of about 1,201,564 (309)

Economic Analysis of Organic Rankine Cycle Using R123 and R245fa as Working Fluids and a Demonstration Project Report

open access: yesApplied Sciences, 2019
The organic Rankine cycle (ORC) is a popular technology used in waste heat recovery and low-grade heat utilization, which are two important measures to solve the problems brought by the energy crisis.
Xinxin Zhang   +4 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Experimental Study on Heat Loss of a Single Screw Expander for an Organic Rankine Cycle System

open access: yesFrontiers in Energy Research, 2020
For displacement expanders, the irreversible losses include leakage, friction, heat dissipation, and flow resistance. Currently, the research on the heat loss of expanders is scarce, especially with regards to experimental studies.
Wei Wang   +9 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Inorganic Salt Hydrate for Thermal Energy Storage

open access: yesApplied Sciences, 2017
Using phase change materials (PCMs) for thermal energy storage has always been a hot topic within the research community due to their excellent performance on energy conservation such as energy efficiency in buildings, solar domestic hot water systems ...
Ning Xie   +5 more
doaj   +1 more source

Experimental investigation of seepage and heat transfer in rough fractures for enhanced geothermal systems

open access: yesRenewable Energy, 2019
Enhancing the heat transfer efficiency between working fluids and hot dry rocks (HDRs) in fracture reservoirs is important. In this paper, we present the seepage and convective heat transfer experiment to investigate the behavior of distilled water in ...
Yibin Huang   +4 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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