Results 201 to 210 of about 1,693,537 (318)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Satellite quantification of enhanced methane oxidation applied to the stratospheric plume following Hunga Tonga-Hunga Ha'apai eruption. [PDF]

Nat Commun
van Herpen MMJW, De Smedt I, Meidan D, Saiz-Lopez A, Johnson MS, Röckmann T, de Laat J.   +6 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Diffuse subependymoma of the bilateral lateral ventricles. [PDF]

J Clin Imaging Sci
Chen J, Yu X.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Laparoscopic Hepatectomy for Hepatic Inflammatory Myofibroblastic Tumor: A Case Report. [PDF]

Surg Case Rep
Hiura Y, Abe T, Yamaguchi M, Hamaoka M, Kobayashi T, Ohdan H, Toyota K.   +6 more
europepmc   +1 more source

ENHANCE and ONTARGET [PDF]

Preventive Cardiology, 2008
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Giant Kerr rotation enhancement in magneto-plasmonic metamaterials

We report for the first time an order of magnitude enhancement of Kerr rotation in hybrid plasmonic/ferromagnetic metamaterial resonators.
Papasimakis, N., Fedotov, V., Zheludev, N.I., Atmatzakis, E.   +3 more
core  

Hepatic pseudolymphoma with hepatobiliary-phase ring-like hyperintensity on gadoxetic acid-enhanced MRI: radiologic-pathologic correlation with intratumoral fibrosis. [PDF]

BJR Case Rep
Nagata S, Fujimoto N, Tonan T, Chikasue T, Sumi A, Akiba J, Tanoue S.   +6 more
europepmc   +1 more source