Results 181 to 190 of about 109,726 (240)

METHIONINE ENKEPHALIN AND ISOSTERIC ANALOGUES

International Journal of Peptide and Protein Research, 1980
Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino‐ and carboxy‐ terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1 ‐Gly2 peptide bond is replaced ...
Robert Sharpe, Derek Hudson, Michael Szelke   +2 more
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Parallel distribution of methionine-enkephalin-arg6-gly7-leu8 with methionine-enkephalin, leucine-enkephalin and methionine-enkephalin-arg6-phe7 in human and bovine brains

Life Sciences, 1983
Using specific radioimmunoassays(RIAs) for methionine-enkephalin(Met-Enk), leucine-enkephalin(Leu-Enk), methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu) and methionine-enkephalin-Arg6-Phe7 (Met-Enk-Arg-Phe), we studied the regional distribution of these opioid peptides in human and bovine brains.
Takaaki Yoshimasa, Noboru Yanaihara, Yoshio Ikeda, Makoto Sakamoto, Hiroo Imura, Mitsuaki Suda, Kazuwa Nakao   +6 more
openaire   +3 more sources

Crystal structure of methionine-enkephalin

Biochemical and Biophysical Research Communications, 1986
The crystal structure of methionine-enkephalin has been determined by X-ray crystallography. There are two independent pentapeptides in the asymmetric unit and both display extended backbone conformations with their side chains arranged alternately below and above the backbone plane.
Norman Camerman, Arthur Camerman, Donald Mastropaolo   +2 more
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OCCURRENCE OF METHIONINE-ENKEPHALIN-ARG6-GLY⁷-LEU⁸WITH METHIONINE-ENKEPHALIN, LEUCINE-ENKEPHALIN AND METHIONINE-ENKEPHALIN-ARG6-PHE⁷IN HUMAN GASTRIC ANTRUM.

The Journal of Clinical Endocrinology & Metabolism, 1983
Recent studies on the nucleotide sequence of cloned DNA complementary to mRNA for preproenkephalin from bovine adrenal medulla and human pheochromocytoma have revealed that this precursor molecule contains four copies of methionine-enkephalin (Met-Enk) and one copy each of leucine-enkephalin (Leu-Enk), methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg6-
Kosho Takasu, Yoshio Ikeda, Shinichiro Shimbo, Hiroo Imura, Kazuwa Nakao, Takaaki Yoshimasa, Noboru Yanaihara, Mitsuaki Suda, Makoto Sakamoto   +8 more
openaire   +2 more sources

Dopamine and methionine-enkephalin in human brain

Neuroscience Letters, 1982
Abstract The contents of dopamine (determined radioenzymatically) and methionine-enkephalin (assayed by a radioimmunoassay) were measured in several areas of the human brain. The peptide was principally localized in dopamine-rich structures. In patients with Parkinson's disease, in contrast to the general dopamine deficiency, the reduction in ...
Brigitte Berger, H. Taquet, François Cesselin, F. Javoy-Agid, A. Ploska, Yves Agid, M. Hamon, J.C. Legrand, Patricia Gaspar   +8 more
openaire   +3 more sources

ENZYME IMMUNOASSAY FOR METHIONINE‐ENKEPHALIN SULFOXIDE

Clinical and Experimental Pharmacology and Physiology, 1990
SUMMARY1. An immunoassay technique employing an enzyme‐labelled ligand was developed for the sulfoxide derivative of the opioid peptide methionine‐enkephalin (MOE).2. The sensitivity of the enzyme immunoassay (EIA) was approximately twofold higher than that achieved in the radio‐immunoassay (RIA) using tritiated ligand.
Jean E. Olley, George K. L. Tiong
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Totalsynthese von Methionin‐Enkephalin

Angewandte Chemie, 1976
Zwanzigfache Normorphin‐Wirkung zeigt das aus Schweinehirn isolierte Pentapeptid (1), das man infolgedessen auch als „endogenes Opiat”︁ bezeichnet hat. Jetzt wird die Totalsynthese dieses Stoffes beschrieben magnified image.
Wolfgang Voelter, Emanuel Pietrzik, Claus Bürvenich, Hans Horn, Hubert Kalbacher   +4 more
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Methionine Enkephalin: Clinical Pharmacology [PDF]

, 1986
Earlier studies indicated that methionine enkephalin infusions (1,000 micrograms) in normal volunteers induced facial flushing, general vasodilation and noisy stomach (borborgymi). Blood pressure and pulse rate were normal in all experiments. Plasma levels of pancreatic polypeptide, somatostatin, T3 and T4, TSH, FSH, PRL, ACTH, and GH were unchanged ...
R. Richter, J. L. Valentine, G. C. Miller, M. Fesen, Anthony J. Murgo, S. Solomon, L. Edwards, Robert E. Faith, N. P. Plotnikoff   +8 more
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Ultraviolet A eye irradiation ameliorates colon carcinoma induced by azoxymethane and dextran sodium sulfate through β‐endorphin and methionine‐enkephalin

Photodermatology, Photoimmunology & Photomedicine, 2017
We previously reported that ultraviolet (UV) A eye irradiation reduces the ulcerative colitis induced by dextran sodium sulfate (DSS). This study examined the effects of UVA on colon carcinoma induced by azoxymethane (AOM) and DSS.
K. Hiramoto, S. Yokoyama, Y. Yamate
semanticscholar   +1 more source

Cross tolerance between morphine and methionine-enkephalin [PDF]

Nature, 1976
TOLERANCE and dependence are characteristic symptoms in man during prolonged use of opiates. We have pointed out1 that for an understanding of these phenomena the interaction between endogenous enkephalin and exogenous opiates is of importance. Normally, enkephalin can be assumed to control inhibitory mechanisms determining the rate of neurotransmitter
Hans W. Kosterlitz, Angela A. Waterfield, John Hughes   +2 more
openaire   +2 more sources