Results 201 to 210 of about 109,726 (240)

Biosynthetic origin and receptor conformation of methionine enkephalin

Nature, 1976
RECENT reports have shown that the brain contains an endogenous peptide with opiate-like activity1–3 and similar peptides have been found in the pituitary4,5,13. One of the brain peptides, known as methionine enkephalin, was identified as a pentapeptide Tyr–Gly–Gly–Phe–Met6, and evidence was presented that a minor component may have leucine in place of
C. R. Snell, Derek G. Smyth, A.F. Bradbury   +2 more
openaire   +3 more sources

Methionine enkephalin metabolism by murine macrophage ectopeptidase(s)

Regulatory Peptides, 1994
Ectopeptidases which hydrolyze opioid and other neuropeptides have been identified in brain, kidney and intestine. In this study, identification of the enzymes metabolizing the opioid peptide methionine enkephalin (YGGFM) in murine macrophages was undertaken.
Louis B. Hersh, Gene L. Cottam, Bonnie C. Miller, Ackroyd A   +3 more
openaire   +3 more sources

Stable isolated symmetrical anhydrides of N alpha-9-fluorenylmethyloxycarbonylamino acids in solid-phase peptide synthesis. Methionine-enkephalin synthesis as an example.

International journal of peptide & protein research, 2009
The synthesis and isolation of symmetrical anhydrides of N alpha-9-fluorenylmethyloxycarbonyl (Fmoc) amino acids using water soluble carbodiimide is described.
E. Heimer, C. D. Chang, T. Lambros, J. Meienhofer   +3 more
semanticscholar   +1 more source

Proton Magnetic Resonance Studies of Methionine Enkephalin

Biochemical and Biophysical Research Communications, 1996
In the literature there exist two conflicting pieces of data concerning the thermodynamics of the Cu(2+)-methionine enkephalin complex. One study utilized 1H nuclear magnetic resonance (NMR) to study the solution phase Cu(2+)-enkephalin binding and reported a strong interaction over a wide pH range. Another study utilized potentiometry to measure a log
Peter Tonui, S. S. Toporek, Angela Miller, Dave Powell, Thomas J. Manning   +4 more
openaire   +3 more sources

Methionine enkephalin inhibits colorectal cancer by remodeling the immune status of the tumor microenvironment.

International Immunopharmacology, 2022
Xiaonan Wang, Shunlin Li, Siqi Yan, Y. Shan, Xiao Wang, Zhai Jingbo, Yuanyuan Wang, Fengping Shan, N. Griffin, Xun Sun   +9 more
semanticscholar   +1 more source

Methionine enkephalin and isosteric analogues. I. Synthesis on a phenolic resin support.

International journal of peptide & protein research, 2009
An efficient synthesis of methionine enkephalin using a phenolic resin support is described. Analogues modified at their C-termini, such as peptide acids, amides, methyl esters and compounds formed by their reduction, were prepared conveniently from ...
Derek Hudson, G. Kenner, Robert Sharpe, Michael Szelke   +3 more
semanticscholar   +1 more source

CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver

Gut, 2009
Objective To examine the role of CD10, a characteristic marker of liver metastasis of colorectal cancers (CRCs). Design The effect of CD10 and Met-enkephalin (MENK) in CD10-positive and -negative human CRC cells was investigated under in vitro and in ...
H. Kuniyasu, Yi Luo, K. Fujii, T. Sasahira, Y. Moriwaka, N. Tatsumoto, Takamitsu Sasaki, Yuichi Yamashita, Hitoshi Ohmori   +8 more
semanticscholar   +1 more source

Self-administration of methionine enkephalin into the nucleus accumbens

Pharmacology Biochemistry and Behavior, 1984
Microinfusions of the endogenous opiate neurohumor, methionine enkephalin, into the nucleus accumbens initiated a reinforcing stimulus in a dose-related manner. The reinforcing nature of this intracranial self-administration was evaluated with intermittent schedules of reinforcement and a two-lever discrimination procedure.
John D. Lane, Nicholas E. Goeders, James E. Smith   +2 more
openaire   +2 more sources

Methionine-enkephalin and vasopressin in SHR: effects of dehydration

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1986
Enkephalins are found in the posterior pituitary, can alter vasopressin secretion, and have greater pressor effects in spontaneously hypertensive rats (SHR) than in Wistar-Kyoto (WKY) rats. Measurement of the plasma methionine-enkephalin concentration (PMet-Enk) has provided equivocal results in humans and has not been reported in rats.
Joan T. Crofton, Leonard Share, D. P. Brooks, K. Ota   +3 more
openaire   +3 more sources

Methionine-enkephalin related glycoconjugates. Synthesis and biological activity.

International journal of peptide & protein research, 2009
A series of glycoconjugates, in which [Met5]enkephalin or [D-Ala2,Met5]enkephalin have been linked through an ester bond to the HO-6 of various D-glycopyranose moieties, were synthesized by classical solution methods.
Š. Horvat, J. Horvat, L. Varga-Defterdarović, K. Pavelić, N. N. Chung, P. Schiller   +5 more
semanticscholar   +1 more source