Results 171 to 180 of about 744,448 (280)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bilateral Adrenal Metastases From Breast Cancer 14 Years After Remission: Diagnostic Value of "Adrenal Thickening". [PDF]

JCEM Case Rep
Martinez-Cruz M, Sharma S, Kannuswamy R, Edwards B, James O, Corsino L.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Multidisciplinary Management of Phenytoin-Induced Gingival Enlargement: A Case Report. [PDF]

Cureus
Gupta D, Chowdhary Z, Mehrotra S, Chaudhary B, Bhatnagar A.   +4 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Histopathological and Molecular Characterization of Amlodipine-Induced Gingival Enlargement: Insights into Fibrotic Mechanisms. [PDF]

Pharmaceuticals (Basel)
Mojsilović J, Kostić M, Vujović Ristić S, Stevanović M, Stević M, Knežević S, Jovičić N.   +6 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple sclerosis. [PDF]

Cell Rep Med
Fleischer V, Schraad M, Gonzalez-Escamilla G, Schneider R, Brummer T, Steffen F, Protopapa M, Hanuscheck N, Salmen A, Meuth SG, Luessi F, Wiendl H, Klotz L, Gold R, Lukas C, Bittner S, Groppa S, Zipp F.   +17 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Aggressive Prostatic Stromal Sarcoma Mimicking Benign Prostatic Enlargement in a Middle-Aged Man: A Case Report. [PDF]

Clin Case Rep
Saleh F, Lekei E, Cheyo ZI, Faki R, Nnko G, Makupa G, Mohamed A, Bright F, Mremi A.   +8 more
europepmc   +1 more source