Results 181 to 190 of about 1,168,064 (316)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Characteristics of Pore-Fracture Development in Coal Reservoirs Constrained by Coal Facies: A Case Study of the Ningdong Coalfield

ACS Omega
Jincheng Ye, Peirong Zhao, Wei He, Zengqing Liu, Baojian Shen, Shihu Zhao, Xinjun Chen, Jiaqi Zhang, Tianyun Wang   +8 more
doaj   +1 more source

Numerical Simulation of Biochar Substitution for Sintering Process Combining Coarse Particle Size and Selective Oxygen Enrichment. [PDF]

ACS Omega
Wang Z, Cai J, Kong X, Yu M, Zhao L, Yan C, Liu A, Wu H.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Artificial Sweeteners and Autoimmune Diseases: Insights From Integrative Bioinformatics and Mendelian Randomization. [PDF]

Food Sci Nutr
Liu Y, Huang J, Hu X, Tian S, Li J, Tan S, Dong W.   +6 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Preparation of Amphiphilic Janus-SiO2 Nanoparticles and Evaluation of the Oil Displacement Effect

ACS Omega
Shanfa Tang, Zhiguo Sun, Yuanwu Dong, Yangwen Zhu, Hao Hu, Rui Wang, Haiying Liao, Quanqi Dai   +7 more
doaj   +1 more source

Subgingival microbiota composition is associated with brain health in the general population-the PAROMIND study. [PDF]

EBioMedicine
Petersen M, Walther C, Borof K, Heydecke G, Beikler T, Alawi M, Müller C, Nägele FL, Zyriax BC, Fiehler J, Gallinat J, Kühn S, Twerenbold R, Bang C, Thomalla G, Cheng B, Aarabi G.   +16 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source