Results 241 to 250 of about 1,168,064 (316)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Enriching Anthropology, Enriching by Anthropology

Abstracts of the Annual Meeting of the Japanese Society of Cultural Anthropology, 2010
openaire   +1 more source

Pan-Cancer Analysis of a Depression-Related Gene Signature Identifies an Immunosuppressive Tumor Microenvironment and Links to Immunotherapy Response in Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Chen G, Yin B, Khan M, Yang Y, Sun Q, Zhang T, Hu H, Lin J.   +7 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Environmental Concentrations of Herbicide Prometryn Increase the Susceptibility of Reef-Building Corals to Nitrate Stress. [PDF]

Environ Sci Technol
Li Q, Zhou Y, Kang W, Tang X, Hu B, Tang Z, Wu F, Downs CA, Zhao H.   +8 more
europepmc   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Hydrocarbon Generation Potential, Paleoenvironmental Conditions, and Organic Matter Enrichment of the Fengcheng Formation Black Shales in the Hala'alat Mountain, NW Junggar Basin: Chemostratigraphic Insights from Well HQ‑6. [PDF]

ACS Omega
Li Z, Zhang S, Zhou J, Song M, Bai J, Zhang L, Jia Y, Liu R, Guo H, Hu'anishen J, Wei Y.   +10 more
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Heads and tails of individual differences: the role of environmental complexity in cognitive development of juvenile lobsters. [PDF]

Anim Cogn
Mazza V, Latini L, Burini G, De Donno R, Scalvini M, Benedetti D, Liuzzo M, Grignani G, Nascetti G, Malavasi S, Tricarico E, Canestrelli D, Carere C.   +12 more
europepmc   +1 more source