Results 51 to 60 of about 5,030 (185)

Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis

European Journal of Immunology, Volume 55, Issue 8, August 2025.
Exploiting a high‐dimensional mass cytometry approach, we demonstrate that CD56+ lymphocytes promote Mycobacterium tuberculosis dormancy by delivering granulysin, a cytotoxic effector molecule with known antimicrobial activity. ABSTRACT Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat.
Sarah Schmidiger, Erin F. McCaffrey, Jan M. Schmidt, Owais Abdul Hameed, Max Mpina, Anneth Tumbo, Elirehema Mfinanga, Frederick Haraka, Hellen Hiza, Mohamed Sasamalo, Jerry Hella, Michael Walch, Jacques Fellay, Sébastien Gagneux, Klaus Reither, José M. Carballido, Ainhoa Arbués, Damien Portevin   +17 more
wiley   +1 more source

Ensaio clínico com um novo anti-epiléptico (barbexaclone)

Arquivos de Neuro-Psiquiatria, 1977
Foi experimentado um novo anti-epiléptico (barbexaclone) em 48 pacientes que apresentavam 67 tipos de crises, destacando-se o fato de que todos eram casos considerados maus, seja pela intensidade das manifestações epilépticas, seja para refratariedade a ...
José Hermínio Bragatti, Gerda Horn Caleffi, Flávio José Prenna   +2 more
doaj   +1 more source

Impact of point‐of‐care maternal viral load testing at delivery on vertical HIV transmission risk assessment and neonatal prophylaxis: a cluster randomized trial

Journal of the International AIDS Society, Volume 28, Issue 8, August 2025.
Abstract Introduction Despite global reductions in vertical HIV transmission (VHT), 120,000 children newly acquired HIV in 2023. High maternal viral load (VL) is a major risk factor for VHT. We estimated the impact of point‐of‐care (PoC) maternal VL testing at delivery in profiling the risk of VHT and its impact on appropriate postnatal prophylaxis for
Anange Fred Lwilla, Kira Elsbernd, Siriel Boniface, Raphael Edom, Arlete Mahumane, Bindiya Meggi, W. Chris Buck, Joaquim Lequechane, Kassia Pereira, Nhamo Chiwerengo, Falume Chale, Chishamiso Mudenyanga, Dadirayi Mutsaka, Marianna Mueller, Nyanda E. Ntinginya, Nuno Taveira, Michael Hoelscher, Ilesh Jani, Arne Kroidl, Issa Sabi, and the LIFE Study Consortium   +20 more
wiley   +1 more source

Avaliação do risco de viés dos ensaios clínicos referenciados nas notas técnicas sobre os anticoagulantes orais diretos disponíveis no e-NatJus

Medicina, 2023
Objetivo: Avaliar e classificar os riscos de vieses dos ensaios clínicos (EC) que compõem as NTs referentes à solicitação dos DOAC. Métodos: As NTs relacionadas à solicitação dos DOAC apixabana, dabigatrana, edoxabana e rivaroxabana foram selecionadas ...
Mara Luiza de Paiva Domingues, Nívea Aparecida de Almeida, Denner Henrique Isaías Souza, Nayara Ragi Baldoni, Danyelle Romana Alves Rios, Carina Carvalho Silvestre, André Oliveira Baldoni   +6 more
doaj  

Socio‐demographic and geographic disparities in HIV prevalence, HIV testing and treatment coverage: An analysis of 108 national household surveys in 33 African countries

Journal of the International AIDS Society, Volume 28, Issue 8, August 2025.
Abstract Introduction Socio‐demographic and geographic disparities in HIV prevalence, uptake of HIV testing and access to antiretroviral therapy (ART) persist in high HIV burden countries. Understanding demographic, spatial and temporal factors can guide interventions.
Adrien Allorant, Salome Kuchukhidze, James Stannah, Yiqing Xia, Sanele S. Masuku, Gatien K. Ekanmian, Jeffrey W. Imai‐Eaton, Mathieu Maheu‐Giroux   +7 more
wiley   +1 more source

Representações sociais de crianças participantes de um ensaio clínico sobre o pesquisador: de detentor do saber à criança curiosa

Saúde e Sociedade, 2014
Intervenções educativas constituem importantes ferramentas para a ampliação do conhecimento científico e em ensaios clínicos devem contribuir para a tomada de decisão quanto à participação na pesquisa.
Maria Flávia Carvalho Gazzinelli, Vânia de Souza, Fernanda Bicalho Pereira, Lucas Henrique Lobato de Araujo, Marconi Moura Fernandes, Patrícia Fernanda de Melo, Relbson de Matos Costa   +6 more
doaj   +1 more source

A novel approach for feline sporotrichosis pathogen detection based on loop‐mediated isothermal amplification

Veterinary Dermatology, Volume 36, Issue 4, Page 474-484, August 2025.
Background – Sporotrichosis is a chronic, mycotic infection caused by fungi of the genus Sporothrix. Zoonotic sporotrichosis occurs mainly through S. brasiliensis transmission, resulting from the organism's traumatic introduction via scratches or bites, or contact with exudate from contaminated cats.
Steffanie Amadei, Júlia Campos, Amanda Bertão‐Santos, Alis Frentzel, Hugo Ávila, Fabiana S. Monti, Marconi R. Farias   +6 more
wiley   +1 more source

Intervenções para cuidadores de sobreviventes de acidente vascular cerebral: revisão sistemática

Revista Panamericana de Salud Pública, 2018
Objetivo. Sintetizar e criticar a produção científica sobre as intervenções desenvolvidas para reverter a sobrecarga de cuidado e os fatores associados em cuidadores de sobreviventes de acidente vascular cerebral (AVC). Método.
Jaine Kareny da Silva, Karla Ferraz dos Anjos, Vanessa Cruz Santos, Rita Narriman Silva de Oliveira Boery, Darci de Oliveira Santa Rosa, Eduardo Nagib Boery   +5 more
doaj   +1 more source

Household economic impact of HIV‐associated cryptococcal meningitis in five countries in Southern and Eastern Africa

Journal of the International AIDS Society, Volume 28, Issue 6, June 2025.
Abstract Introduction HIV‐associated cryptococcal meningitis is the second leading cause of AIDS‐related mortality. Cryptococcal meningitis is a poverty‐related disease and the majority of cases occur in settings where resources are limited and access to quality care is often linked to an individual's ability to pay for services.
David S. Lawrence, Charles Muthoga, Jack Adams, Antoinette Buhle Ndweni, David R. Boulware, Chimwemwe Chawinga, Kyla Comins, Eltas N. Dziwani, Admire Hlupeni, Mina C. Hosseinipour, Samuel Jjunju, Cecilia Kanyama, Tshepo B. Leeme, Graeme Meintjes, David B. Meya, Mosepele Mosepele, Melanie Moyo, Henry C. Mwandumba, Conrad Muzoora, Chiratidzo E. Ndhlovu, Edwin Nuwagira, Charlotte Schutz, Lillian Tugume, Darlisha Williams, Síle F. Molloy, Timothée Boyer‐Chammard, Nabila Youssouf, Shabbar Jaffar, Louis W. Niessen, Thomas S. Harrison, Lucy Cunnama, Joseph N. Jarvis, the AMBITION Study Group   +32 more
wiley   +1 more source

Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis

Veterinary Dermatology, Volume 36, Issue 3, Page 302-313, June 2025.
Background – Malassezia pachydermatis (MP) is implicated in severe dermatitis and otitis externa (OE) of companion animals and recently gained attention for its increasing resistance to azole compounds. For this reason, developing novel therapeutic strategies is of great interest. In a previous work, we used reference yeast isolates to evaluate several
Costanza Spadini, Nicolò Mezzasalma, Amienwanlen Eugene Odigie, Andrea Angeli, Fabrizio Carta, Silvia Selleri, Emanuele Gandolfo, Simone Taddei, Valentina Franceschi, Sergio Minesso, Claudiu T. Supuran, Clotilde Silvia Cabassi   +11 more
wiley   +1 more source