Results 41 to 50 of about 42,506 (260)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Duality origami: Emergent ensemble symmetries in holography and Swampland
Physics Letters BWe discuss the interrelations between several ideas in quantum gravity – holography, the Swampland, and the concept of ensemble averaging. To do so, we study ensemble averages of Narain-type theories associated with general even quadratic forms and their
Meer Ashwinkumar +2 more
doaj +1 more source
The perceptual average in ensemble representation: Neither perceptual nor an average. [PDF]
Atten Percept PsychophysAbstract This report targets the claim that gist representations of visual stimuli, called “ensemble averages”, are perceptual representations of statistics pertaining to stimuli. We report predictions of a mathematical model based on classical memory architectures which assumes ensemble averages are statistical approximations to ...
Zepp J, Dubé C.
europepmc +4 more sources
A Note on Functional Averages over Gaussian Ensembles [PDF]
Journal of Probability and Statistics, 2013 We find a new formula for matrix averages over the Gaussian ensemble. LetHbe ann×nGaussian random matrix with complex, independent, and identically distributed entries of zero mean and unit variance. Given ann×npositive definite matrixAand a continuous functionf:ℝ+→ℝsuch that∫0∞e-αt|f(t)|2dt<∞for everyα>0, we find a new formula for the ...
Gabriel H. Tucci, Maria V. Vega
openaire +4 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Closed universes, factorization, and ensemble averaging
Journal of High Energy PhysicsWe study closed universes in holographic theories of quantum gravity. We argue that within any fixed theory, factorization implies there is one unique closed universe state.
Mykhaylo Usatyuk, Ying Zhao
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source