Results 181 to 190 of about 31,411 (361)

Activation of Nuclear Receptor CAR: A Pathway to Delay Aging through Enhanced Capacity for Xenobiotic Resistance

open access: yesAdvanced Science, Volume 12, Issue 12, March 27, 2025.
The authors uncovered that targeting the constitutive androstane receptor (CAR) might decelerate the aging process. Employing models like C. elegans and mice, they determined that CAR agonists CITCO and TCPOBOP can extend both the lifespan and healthspan.
Jing Yu   +12 more
wiley   +1 more source

Synthesis of salcaprozate sodium and its significance in enhancing pancreatic kininogenase absorption performance

open access: yesPharmacology Research & Perspectives
We conducted pharmacokinetic research wherein salcaprozate sodium (SNAC) was utilized as a penetration enhancer by incorporating it into pancreatic kininogenase (PK) to improve the bioavailability of pancreatic kininogenase enteric‐coated tablets.
Zhong Lv   +6 more
doaj   +1 more source

Bioavailability of pyridoxal phosphate from enteric-coated tablets. I. Apparent critical dissolution pH and bioavailability of commercial products in humans.

open access: bronze, 1985
Nahoko Kaniwa   +14 more
openalex   +2 more sources

AI‐Driven TENGs for Self‐Powered Smart Sensors and Intelligent Devices

open access: yesAdvanced Science, EarlyView.
Triboelectric nanogenerators (TENGs) enable sustainable energy harvesting and self‐powered sensing but face challenges in material optimization, fabrication, and stability. Integrating artificial intelligence (AI) enhances TENG performance through machine learning, improving energy output, adaptability, and predictive maintenance.
Aiswarya Baburaj   +4 more
wiley   +1 more source

Synergistic Machine Learning Guided Discovery of ABa3(BSe3)2X (A = Rb, Cs; X = Cl, Br, I): A Promising Family as Property‐Balanced IR Functional Materials

open access: yesAdvanced Science, EarlyView.
A synergistic framework for interpretable ML‐assisted target discovery of selenoborates is developed. ABa3(BSe3)2X (A = Rb, Cs; X = Cl, Br, I) are successfully predicted and synthesized, exhibiting significant potential to be promising IR functional materials. This work promotes the cooperation of ML technology and materials science.
Yihan Yun   +4 more
wiley   +1 more source

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

open access: yesAdvanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge   +16 more
wiley   +1 more source

Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single‐center, open‐label, prospective study

open access: yesIbrain, EarlyView., 2023
Compound porcine perebroside and ganglioside injection (CPCGI) was used to treat ischemic stroke. However, there was no clinical evidence of low‐dose CPCGI. We conducted a clinical study to analyze whether the clinical results of low‐dose and standard‐dose CPCGI in patients with ischemic stroke were different.
Ya Chen   +8 more
wiley   +1 more source

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