Results 231 to 240 of about 31,411 (361)

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo‐controlled Trial in Constipation

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1284-1291, May 2025.
Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo‐controlled cross‐over trials were performed, one using a single dose of Bisacodyl 5 mg while the second dosed daily for 3 consecutive days.
Abdulsalam Aliyu   +13 more
wiley   +1 more source

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

open access: yesDrug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman   +9 more
wiley   +1 more source

Advancing aqueous zinc‐ion batteries with carbon dots: A comprehensive review

open access: yesEcoEnergy, EarlyView.
Carbon dots (CDs), with their distinctive structure and superior electrochemical properties, represent an innovative class of carbon‐based materials with broad potential applications for optimizing aqueous zinc‐ion batteries (AZIBs) performance. This comprehensive review highlights the potential application of CDs in AZIBs.
Mingying Chen   +7 more
wiley   +1 more source

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