Results 71 to 80 of about 31,411 (361)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease

Scientific Reports, 2021
Peptide therapeutics are increasingly used in the treatment of disease, but their administration by injection reduces patient compliance and convenience, especially for chronic diseases.
Sergei Pechenov, Jefferson Revell, Sarah Will, Jacqueline Naylor, Puneet Tyagi, Chandresh Patel, Lihuan Liang, Leo Tseng, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Anish Konkar, Joseph Grimsby, J. Anand Subramony   +13 more
doaj   +1 more source

Water dispersible microbicidal cellulose acetate phthalate film [PDF]

, 2003
BACKGROUND: Cellulose acetate phthalate (CAP) has been used for several decades in the pharmaceutical industry for enteric film coating of oral tablets and capsules.
A Robert Neurath, A Stone, AC Gerbase, AJ Nahmias, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AV Kabanov, B Kovacs, C Coggins, CV Uglea, D Quintanar-Guerrero, DL Jones, DS Jones, G Green, G Ramjee, GN Milligan, H Arwidsson, H Chakraborty, H Ibrahim, H.L.,Jr. Martin, IJ Rosenstein, J Liao, JA Rottingen, JM Mann, JR Dyer, K Stiasny, KA Gates, KH Manson, KR Tambweker, L Van Damme, M Over, M Ratterree, MK Stafford, Nathan Strick, P Sakellariou, PL Perine, R Duncan, R Rustomjee, RE Roddy, RJ Harwood, RN Fichorova, RN Fichorova, SD Holmberg, SJ Reynolds, SR Goskonda, T Gyotoku, T Kawamura, T Kietzke, T Vemba, V Baeyens, V Rosilio, Yun-Yao Li   +57 more
core   +2 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Efficacy and safety of the Chinese herbal formula Hewei Jiangni recipe for NERD with cold-heat complex syndrome: study protocol for a double-blinded randomized controlled trial

Trials, 2021
Background Proton pump inhibitor (PPI) is effective for the treatment of nonerosive gastroesophageal reflux (NERD), but long-term use of PPI is prone to have complications and recurrence after withdrawal.
Xiaosi Zhang, Yuan Cheng, Xiaohong Li, Xiang Tan, Lei Shi, Xiaojun Shi, Xiancui Zhang, Chun’e Xie, Junxiang Li   +8 more
doaj   +1 more source

Deep learning classification of large-scale point clouds: A case study on cuneiform tablets [PDF]

arXiv, 2022
This paper introduces a novel network architecture for the classification of large-scale point clouds. The network is used to classify metadata from cuneiform tablets. As more than half a million tablets remain unprocessed, this can help create an overview of the tablets.
arxiv  

Berry Preparations and Extracts [PDF]

, 2011
A method for deriving compositions having antioxidant and anti-inflammatory activity from berries is provided. The method results in a berry extract compositions having stable anthocyanin content. In one aspect, the method comprises exposing a berry to a
Dai, Jin, Gallicchio, Vincent S., Mumper, Russell J.   +2 more
core   +1 more source

Going Natural: Using polymers from nature for gastroresistant applications [PDF]

, 2017
Nutraceuticals provide an additional health or medicinal benefit besides their nutritional value and are therefore marketed for the prevention and treatment of certain conditions.
Barbara Conway, Hamid Merchant, Joao A.C. Barbosa, null null   +3 more
core   +1 more source

Mechanisms of De‐icing by Surface Rayleigh and Plate Lamb Acoustic Waves

Advanced Engineering Materials, EarlyView.
Ice accretion impacts daily life, renewable energy generation, maintenance, and security in industries and aeronautics. Acoustic waves (AW) are a promising method for ice removal, although de‐icing mechanisms require further investigation to optimize energy efficiency.
Shilpi Pandey, Jaime del Moral, Stefan Jacob, Laura Montes, Jorge Gil‐Rostra, Alejandro Frechilla, Atefeh Karimzadeh, Victor J. Rico, Raul Kanter, Niklas Kandelin, Carmen López‐Santos, Heli Koivuluoto, Luis Angurel, Andreas Winkler, Ana Borrás, Agustin R. González‐Elipe   +15 more
wiley   +1 more source

FORMULATION AND IN VITRO EVALUATION OF RAMELTEON TABLETS FOR COLON DRUG DELIVERY SYSTEM BY COMPRESSION COATING [PDF]

, 2021
Objective: Ramelteon, is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABAA receptors.
CVS, PHANINDRA, M., TRINADHA RAO, M., YAMINI, Y., PARIMALA, Y., SRINIVASA RAO   +4 more
core   +1 more source