Results 51 to 60 of about 51,756 (285)

Formulation and Drug Release of Isoxsuprine HCL Enteric Coated Tablets [PDF]

, 2016
The aim of the study is to formulate and evaluate enteric coated tablets using Isoxsuprine Hydrochloride as a model drug. Different core tablets and enteric coated tablets were prepared and drug release was studied. Isoxsuprine Hydrochloride core tablets
Nagamani, V. (V)
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation

Pharmaceutics, 2023
Oral delivery of peptides and biological molecules promises significant benefits to patients as an alternative to daily injections, but the development of these formulations is challenging due to their low bioavailability and high pharmacokinetic ...
Puneet Tyagi, Chandresh Patel, Kimberly Gibson, Fiona MacDougall, Sergei Y. Pechenov, Sarah Will, Jefferson Revell, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Umar Maharoof, Joseph Grimsby, J. Anand Subramony   +12 more
doaj   +1 more source

Abundance and Distribution of Enteric Bacteria and Viruses in Coastal and Estuarine Sediments—a Review [PDF]

, 2016
The long term survival of fecal indicator organisms (FIOs) and human pathogenic microorganisms in sediments is important from a water quality, human health and ecological perspective.
Abdelzaher, Alcântara, Alkan, Allison, Allwood, Amel, Anderson, Arana, Arnold, Arnon, Artz, Asakura, Atkinson, Auer, Avery, Ayrapetyan, Ayrapetyan, Bae, Banning, Bari, Bauman, Berthe, Bilge, Bitton, Bonilla, Borade, Bosch, Bryers, Burton, Busscher, Byappanahalli, Byappanahalli, Cai, Cangelosi, Cao, Carlson, Carr, Carreira, Castro, Cellini, Chan, Charles, Cheville, Chigbu, Chrysikopoulos, Chrysikopoulos, Cook, Cooper, Costerton, Cox, Crabill, Czajkowska, Dancho, Danovaro, Darcan, Davies, de Brauwere, de Brouwer, Deloffre, Dobrindt, Doré, Dowd, Drummond, Drummond, Duhamel, Dulbecco, Ervin, Evanson, Farkas, Ferguson, Filip, Filippini, Fongaro, Foppen, Foppen, Fu, Fukushima, Furtak, Garzio-Hadzick, Geldreich, Gerba, Gerba, Gerba, Gerba, Gerba, Gilbert, Gin, Girones, Goldscheider, Gomez-Suarez, Gottenbos, Goyal, Green, Greening, Guizien, Gwyther, Hadjiev, Haller, Halpern, Hamdan, Harvey, Hassard, Hazen, He, Heijnen, Henry, Henson, Hermansson, Hong, Howell, Howlett, Huang, Ikner, Ishii, Jamieson, Jamieson, Jiang, Jin, John, Johnson, Junkins, Kay, Kerr, Khan, Kierek, Kim, Kirschner, Kitajima, Klayman, Korajkic, Korber, LaBelle, LaBelle, Le Guyader, Lee, LeJeune, Lemos, Lewis, Lewis, Li, Lieleg, Liew, Lorite, Lothigius, Lowther, Lucena, Luna, Madsen, Malham, Malic, Maule, McGee, Meays, Melnick, Meschke, Mills, Miura, Moce-Llivina, Muirhead, Nasser, Neave, Nocker, Norman, Obiri-Danso, Ogorzaly, Ohtomo, Oliver, Oliver, Oliver, Oliver, Ouattara, Ouattara, Pachepsky, Pachepsky, Pachepsky, Paez-Espino, Pang, Park, Passerat, Paul, Payne, Peneau, Perkins, Petterson, Piggot, Pinto, Port, Poulsen, Props, Quignon, Quilliam, Quilliam, Ramaiah, Ramamurthy, Randa, Rao, Rao, Rao, Ren, Rice, Rice, Ritchie, Rock, Roper, Roper, Rosenwasser, Rozen, Ryu, Saby, Samandoulgou, Scherber, Schijven, Scholl, Schultz-Fademrecht, Sen, Setti, Shahrampour, Shelton, Siem-Jorgensen, Signoretto, Singh, Sinton, Skraber, Skraber, Smets, Smith, Soares de Lima Grisi, Solo-Gabriele, Staggemeier, Staggemeier, Stal, Staley, Stapleton, Stenström, Stephenson, Storch, Stumpf, Suhalim, Sutherland, Tan, Thorn, Troussellier, Tsai, van der Mei, Van Houdt, van Loosdrecht, van Loosdrecht, Vignaroli, Vignaroli, Villanueva, Wait, Wallner, Walter, Walters, Wang, Wang, Ward, Watterworth, Weinbauer, Weiss, Williams, Williams, Williamson, Wingender, Wu, Yamahara, Yaron, Yoshida, Young, Zhang   +269 more
core   +5 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Factors Contributing to Drug Release From Enteric-Coated Omeprazole Capsules: An In Vitro and In Vivo Pharmacokinetic Study and IVIVC Evaluation in Beagle Dogs

Dose-Response, 2020
This study was performed to explore factors influencing the release of the proton pump inhibitor omeprazole from enteric-coated capsules in vitro and absorption in vivo in beagle dogs.
Cheng Cui, Jiabei Sun, Xueqing Wang, Zhenxi Yu, Yaqin Shi   +4 more
doaj   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT(3)) receptors ...
Aapro, Ahern, Amy Alexander, Andrew J. Samson, Bearcroft, Bertrand, Bertrand, Bhattacharyya, Boyd, Chanrion, Chen, Chen, Christopher Moffat, Christopher N. Connolly, Connolly, Craig, Faerber, Freeman, Galligan, Guthrie, Hagbom, Hanley, Hansen, Hothersall, Huang, Ilegems, J. Daniel Hothersall, Jiménez-Trejo, Karen A. Bollan, Kittler, Kondaurova, Lau, Lee, Linder, Liu, Liu, Lummis, McKinnon, Mercado, Minami, Mnie-Filali, Muchatuta, Niesler, Riad, Rojas, Schlag, Spiller, Stratz, Tao-Cheng, Turvill, Vikenes, Wade, Wesseldijk, Whalen, Yasuda   +54 more
core   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration [PDF]

, 2016
Background: Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel ...
Antonioli, Luca, Bernardini, Nunzia, Blandini, Fabio, Blandizzi, Corrado, Cerri, Silvia, Colucci, ROCCHINA LUCIA, Cseri, Karolina, Fornai, Matteo, Hask\uf3, Gy\uf6rgy, Ippolito, Chiara, Levandis, Giovanna, Pellegrini, Carolina, Segnani, Cristina, Tirotta, Erika   +13 more
core   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source