Results 271 to 280 of about 1,764,809 (341)

Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery: Update on Clinical Advances. [PDF]

Pharmaceutics
Baral KC, Choi KY.
europepmc   +1 more source

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Advanced Healthcare Materials, EarlyView.
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed   +6 more
wiley   +1 more source

A Phase 1 Randomized, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Enteric-Coated Stabilized Sulforaphane (SFX-01) in Male Participants. [PDF]

Adv Ther
Clack G, Moore C, Ruston L, Wilson D, Koch A, Webb D, Mallard N.   +6 more
europepmc   +1 more source

A Deployable 4D Printed, Mucoadhesive and Magnetically Guided Patch for Local Therapy of Gastric Cancer

Advanced Healthcare Materials, EarlyView.
A new perspective for treatment of gastric cancer is proposed utilizing 4D printing to develop shape morphing, deployable, and magnetically guided local drug releasing patches. The deployed patches are envisioned to adhere at the tumor site to locally deliver high drug amounts.
Dina B. Mahmoud, Martin Börner, Christian Wölk, Michaela Schulz‐Siegmund   +3 more
wiley   +1 more source

Influence of Polymer Film Thickness on Drug Release from Fluidized Bed Coated Pellets and Intended Process and Product Control. [PDF]

Pharmaceutics
Langner M, Priese F, Wolf B.
europepmc   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Prodrug nanotherapy demonstrates in vivo anticryptosporidial efficacy in a mouse model of chronic Cryptosporidium infection.

RSC Pharm
Ranjan AP, Czyzyk DJ, Martinez-Traverso G, Sadiqova A, Valhondo M, Schaefer DA, Spasov KA, Jorgensen WL, Vishwanatha JK, Riggs MW, Castellanos-Gonzalez A, Anderson KS.   +11 more
europepmc   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Toward Noninvasively Imaging pH at the Surface of Implanted Orthopedic Devices in Live Rabbits Using X‐ray Excited Luminescence Chemical Imaging

Advanced Healthcare Materials, EarlyView.
Imaging pH in a live rabbit at the surface of a sensor‐coated titanium plate using X‐ray excited luminescent chemical imaging (XELCI). A raster scanning X‐ray beam generates radioluminescence from a spot on the sensor, and the luminescence passes through the tissue and is collected at two wavelengths to determine local pH.
Unaiza Uzair, Fenglin Wang, Donald Benza, Yash S. Raval, Sriparna Bhattacharya, Tzuen‐Rong J. Tzeng, Jeffrey N. Anker   +6 more
wiley   +1 more source

Novel Core-Shell Aerogel Formulation for Drug Delivery Based on Alginate and Konjac Glucomannan: Rational Design Using Artificial Intelligence Tools. [PDF]

Polymers (Basel)
Illanes-Bordomás C, Landin M, García-González CA.   +2 more
europepmc   +1 more source