Results 31 to 40 of about 7,707 (294)

Erroneous formulation of delayed-release omeprazole capsules: alert for importing countries

BMC Pharmacology and Toxicology, 2017
Background Poor drug quality is a matter of serious concern, especially in countries where drug regulation and law enforcement are constrained by limited resources.
Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, Tep Keila, Tey Sovannarith, Heng Bun Kiet, Eav Dararth, Theingi Zin, Tsuyoshi Tanimoto, Kazuko Kimura   +9 more
doaj   +1 more source

A brief review on recent advancement of tablet coating technology

Journal of Applied Pharmaceutical Research, 2022
A tablet can be defined as a solid unit dosage form. There are several reasons for coating of solid dosage form, the most important reason is to control the release profile & also to control the bioavailability parameters of the APIs (Active ...
Debgopal Ganguly, Soumyadip Ghosh, Pubali Chakraborty, Sumit Mitra, Shounak Chatterjee, Sarmistha Panja, Ananta Choudhury   +6 more
doaj   +1 more source

Exploring Immersion Coating as a Cost-Effective Method for Small-Scale Production of Enteric-Coated Gelatin Capsules

Pharmaceuticals
The coating process for solid dosage forms is widely used in the pharmaceutical industry but presents challenges for small-scale production, needed in personalized medicine and clinical or galenic settings. This study aimed to evaluate immersion coating,
Beatrice Sabbatini, Diego Romano Perinelli, Giovanni Filippo Palmieri, Marco Cespi, Giulia Bonacucina   +4 more
doaj   +1 more source

Development and evaluation of a hot-melt coating technique for enteric coating

Brazilian Journal of Pharmaceutical Sciences, 2012
Conventional enteric coating requires the use of organic based polymers which are equally hazardous to the environment and operating personnel. Hot-melt coating avoids the use of solvents and is a safer and time-saving process.
Arun Trambak Patil, Deepak Shamrao Khobragade, Sandip Annaji Chafle, Amol Prasadrao Ujjainkar, Sudhir Niranjanrao Umathe, Champalal Laxminarayan Lakhotia   +5 more
doaj   +1 more source

Toward Mechanistic Design of Surrogate Buffers for Dissolution Testing of pH-Dependent Drug Delivery Systems

Pharmaceutics, 2020
The in vivo dissolution of enteric-coated (EC) products is often overestimated by compendial in vitro dissolution experiments. It is of great interest to mimic the in vivo conditions as closely as possible in vitro in order to predict the in vivo ...
Johannes Andreas Blechar, Jozef Al-Gousous, Christoph Wilhelmy, Annika Marielina Postina, Marcus Getto, Peter Langguth   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium

Brazilian Journal of Pharmaceutical Sciences, 2014
Isoniazid and rifampicin are considered the first-line medication for preventing and treating tuberculosis. Rifampicin is degraded in the stomach acidic environment, especially when combined with isoniazid, factor contributing to treatment failure.
Fátima Duarte Freire, Manuela Bernardo Câmara, Monique Gomes Dantas, Cícero Flávio Soares Aragão, Túlio Flávio Accioly de Lima e Moura, Fernanda Nervo Raffin   +5 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source