Results 81 to 90 of about 1,761,926 (341)

Printfills: 3D printed systems combining fused deposition modeling and injection volume filling. Application to colon-specific drug delivery [PDF]

, 2019
Three-dimensional printing has become a feasible manufacturing technique for pharmaceutical products providing cheap and accurate freeform systems with a great potential for personalized-dose drugs.
Caraballo Rodríguez, Isidoro, Casas Delgado, Marta, Linares Blasco, Vicente   +2 more
core   +1 more source

Microfluidic Fabrication of Hydrocortisone Nanocrystals Coated with Polymeric Stabilisers

Micromachines, 2016
Hydrocortisone (HC) nanocrystals intended for parenteral administration of HC were produced by anti-solvent crystallisation within coaxial assemblies of pulled borosilicate glass capillaries using either co-current flow of aqueous and organic phases or ...
David F. Odetade, Goran T. Vladisavljevic   +1 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo [PDF]

, 2020
Tremendous progress in synthetic micro/nanomotors has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control in vivo.
Gao, Wei, Hu, Peng, Li, Lei, Wang, Lihong V., Wu, Zhiguang, Yang, Yiran   +5 more
core  

An oral multiparticulate, modified-release, hydrocortisone replacement therapy that provides physiological cortisol exposure [PDF]

, 2014
Objective It is not possible with current hydrocortisone replacement to mimic the diurnal cortisol profile in patients with adrenal insufficiency. Previous attempts with modified-release technology were unsuccessful.
Arlt, Bensing, Bergthorsdottir, Bryan, Clark, Debono, Finkielstain, Johannsson, Krieger, Kushnir, Lennernas, Lovas, Lovas, Mah, Merza, Moeller, Newell-Price, Plat, Roberts, Simon, Spiegel, Tomlinson, Tunn, Verma   +23 more
core   +1 more source

Design of Experiments as a Tool to Optimize the Process of Coating Minitablets with Commercial Gastro-Resistant Coating Mixtures

Pharmaceutics, 2022
According to the Quality by Design (QbD) concept, Design of Experiment (DoE) was used to indicate critical process parameters and optimize the fluid bed coating of minitablets in a laboratory size batch.
Maja Frankiewicz, Małgorzata Sznitowska
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS) [PDF]

, 2014
An increasing human population requires a secure food supply and a cost effective, oral vaccine delivery system for livestock would help facilitate this end. Recombinant antigen adsorbed onto silica beads and coated with myristic acid, was released (∼15%
Aljayyoussi, Arnold, Beatrice Cattoz, Bruce Alexander, Burdock, Clayton, Clench, Cohen, Cottrell, dos Santos, Fleer, Frank Pullen, Glahn, Guinier, Herd, Hoffmann, John C. Mitchell, King, Kunisawa, Marie W. Pettit, Mercier, Müller, Pappin, Paul D.R. Dyer, Peter C. Griffiths, Pockels, Pollok, Ralf Schweins, Richard K. Heenan, Roy, Sakuma, Shaw, Simon C.W. Richardson, Song, Stephen M. King, Stephen R. Wicks, Tang, Torgersen, Tuma, Urbanowski, Vallet-Regi, Wang, Wen, Wilkhu   +43 more
core   +2 more sources

Application and Preparation of Enteric Coating Materials [PDF]

IOP Conference Series: Materials Science and Engineering, 2017
In this paper, polymethacrylate enteric coated materials based on the equal mass of methyl acrylic acid and ethyl acrylate as the main raw materials were synthesized through emulsion polymerization. Omeprazole Enteric-coated Capsules were prepared by the fluidized bed coating technology using above materials as enteric layer and in vitro enteric test ...
Xingzheng Zhang, Xilin Chen, L Wang, Haijun Zhou, Meng Zhou, Yaobin Li, Shulan Yang   +6 more
openaire   +1 more source