Results 141 to 150 of about 40,970 (302)

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Microbial co-existence and stable equilibria in a mechanistic model of enteric methane production : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Mathematics at Massey University, Manawatū Campus, New Zealand [PDF]

, 2016
Globally, 14.5% of all anthropogenic greenhouse gases come from ruminants. One of these is methane, which is produced in the rumen of ruminant animals. Feed is degraded by microbes to produce volatile fatty acids (which are absorbed by the animal) and
Wang, Yuancheng
core  

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

A Sustainable Approach to Managing Invasive Macroalgae: Assessment of the Nutritional Profile and the Potential for Enteric Methane Mitigation of Rugulopteryx okamurae

Oceans
The expansion of the invasive Asian macroalgae Rugulopteryx okamurae along the coasts of the Azores represents a significant challenge for local marine biodiversity.
Helder P. B. Nunes, Cristiana Maduro-Dias, Joana Carvalho, Alfredo Borba   +3 more
doaj   +1 more source

Sri Lankan Contribution to Climate Change by Enteric Fermentation of Large Ruminants: An Overview

Proceedings of International Forestry and Environment Symposium
The Sri Lankan livestock sector (LS) which is essential to rural households' food systems and means of subsistence, contributed to 0.6% of the GDP in 2020. The cattle industry has contributed <40% to the LS. The objective of the review was to determine how Sri Lankan LS, especially ruminants contributed to climate change (CC) by
null Manewa R.M.S.S., null Madumadhawa M.H.D., null Palliyaguru O.G., null Senaratne D.   +3 more
openaire   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Lactose-Fermenting Salmonella Strains Isolated from Patients with Enteritis

Journal of the Japanese Association for Infectious Diseases, 1988
K, Kimura, H, Yamaguchi, M, Sawai, H, Sato   +3 more
openaire   +3 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Strategies to mitigate greenhouse gas and nitrogen emissions in Swiss agriculture: the application of an integrated sector model [PDF]

Environmental impacts of agricultural production, such as greenhouse gas (GHG) and nitrogen emissions, are of major concern for scientists and policy makers throughout the world.
Bernard Lehmann, Michael Hartmann, Robert Huber, Simon Peter   +3 more
core