Results 91 to 100 of about 45,406 (281)

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

EudraVigilance insights: Suspected adverse drug reactions in infants through breastfeeding

British Journal of Clinical Pharmacology, EarlyView.
Aims We aimed to describe suspected adverse drug reactions (ADRs) in infants resulting from medications transmitted through mothers' milk, as reported to the European ADR database, EudraVigilance. The research sought to understand the frequency, seriousness and nature of these ADRs to assess potential risks associated with maternal medication use ...
Ida M. Heerfordt, Ditte Resendal Gotfredsen, Henrik Horwitz, Anette Kirstine Stark, Jon Trærup Andersen, Christina Gade, Ulrik Lausten‐Thomsen, Rasmus Huan Olsen   +7 more
wiley   +1 more source

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza, Michaela Semeraro, Gabrielle Lui, Léo Froelicher‐Bournaud, Laure Choupeaux, Jean‐Marc Treluyer, Sihem Benaboud, Joelle Terzic, Eric Hachulla, Philippe Remy, Jérôme Harambat, Alexandre Karras, Caroline Rousset‐Rouviere, Anne Jolivot, Zahir Amoura, Eric Daugas, Aurélie Hummel, Rémi Salomon, Jean‐Christophe Lega, Stéphane Decramer, Alexandre Belot, Delphine Gobert, Nathalie Costedoat‐Chalumeau, Stanislas Faguer, Isabelle Melki, Noémie Jourde‐Chiche, Brigitte Bader‐Meunier   +26 more
wiley   +1 more source

Salmonella Typhi and Salmonella Paratyphi A elaborate distinct systemic metabolite signatures during enteric fever

eLife, 2014
The host–pathogen interactions induced by Salmonella Typhi and Salmonella Paratyphi A during enteric fever are poorly understood. This knowledge gap, and the human restricted nature of these bacteria, limit our understanding of the disease and impede the
Elin Näsström, Nga Tran Vu Thieu, Sabina Dongol, Abhilasha Karkey, Phat Voong Vinh, Tuyen Ha Thanh, Anders Johansson, Amit Arjyal, Guy Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker, Henrik Antti   +12 more
doaj   +1 more source

THE RASH OF ENTERIC FEVER. [PDF]

The Lancet, 1876
n ...
openaire   +3 more sources

Medications, epilepsy and climate change: Added layers of complexity

British Journal of Clinical Pharmacology, EarlyView.
Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi, Seyhmus Gavas, Sanjay M. Sisodiya   +2 more
wiley   +1 more source

The Infectivity of Enteric Fever [PDF]

, 1898
Elizabeth Saunders
openalex   +1 more source

From silence to academic engagement: How refugee children with disabilities access learning through inclusive ‘artful’ schools in Canada

British Educational Research Journal, EarlyView.
Abstract Many newcomer children spend a ‘silent year’ in elementary school classrooms while they adjust to a new culture and language. This often delays inclusion in learning and forming friendships with peers. For refugee children with disabilities (RCDs) this phase may last for 3 years or more, impacting their mental health and sense of belonging ...
Susan Barber
wiley   +1 more source

A comparative clinical study of efficacy of microimmuno assay with WIDAL-test in enteric fever in children

Journal of the Scientific Society, 2014
The diagnosis of typhoid fever in young children is also a dilemma because of its manifestations and typical presentation may not be seen in all cases.
Gandarajapura Nagaraj Madhu, Shankarappa Srinivasa, Kadahalli Lingegowda Ravikumar, Kuralayanapalya Puttahonnappa Suresh   +3 more
doaj   +1 more source

A Romantic Genius? The Experience of Knowledge that Shaped Werner Heisenberg's Scientific Persona

Berichte zur Wissenschaftsgeschichte, EarlyView.
In 1976, the year that Werner Heisenberg passed away, Armin Hermann published a short biography, titled Werner Heisenberg in Selbstzeugnissen und Bilddokumenten. Since then, historians and biographers have offered their accounts on Heisenberg's life and his contributions to modern physics. Many of these biographies present Heisenberg as a genius.
Elena Schaa
wiley   +1 more source