Results 141 to 150 of about 80,240 (320)

Diagnostic implications and correlates of plasma ADA2 activity and ADA2 variants

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disease manifested as polyarteritis nodosa, stroke, and bone marrow failure. Leveraging an international cohort of 200 DADA2 cases, we aimed to characterize the diagnostic utility of a plasma ADA2 enzyme activity assay and understand the implications of residual ADA2
Jian Yue   +55 more
wiley   +1 more source

Lamivudine and tenofovir pharmacokinetic variability in people with HIV in Papua New Guinea

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Demographics and kidney function contribute to variability in lamivudine and tenofovir drug concentrations. The aim was to assess, for the first time, the pharmacokinetic variability of lamivudine and tenofovir in Papua New Guinean (PNG) HIV/AIDS patients.
Natália Bordin Andriguetti   +4 more
wiley   +1 more source

Effectiveness and safety of interventions for fever‐associated discomfort in children: A systematic review

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Fever is one of the most frequent reasons for paediatric consultations. While traditionally managed by reducing body temperature, recent guidelines emphasize alleviating discomfort as the primary therapeutic goal. Although different interventions have been described to manage fever‐associated discomfort in children, their effectiveness and safety ...
Antonio Corsello   +8 more
wiley   +1 more source

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