Results 151 to 160 of about 80,240 (320)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Experiences with Small-Flaking or Granular Agglutination in Normal, Inoculated and Enteric Fever Cases [PDF]

, 1932
John C. Wyllie
openalex   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Enteric fever in a non-endemic setting: Review of cases over a 12-year period at University hospitals Birmingham, UK

Clinical Infection in Practice
Objectives: Enteric fever remains a common diagnosis in returned travellers to the UK, the majority of which require hospital admission. Increased resistance to antibiotics has complicated the management and rates of vaccine uptake remain unclear ...
Gareth Hughes, Rania Khalil, Susan Wilkinson, Matthew K. O’Shea   +3 more
doaj   +1 more source

Notes on the Origin and Diffusion of Enteric Fever and of Diphtheria [PDF]

, 1881
William E. Strange
openalex   +1 more source

Data for Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica: date estimation 1 [PDF]

, 2018
Salmonella enterica serovar Paratyphi C is the causative agent of enteric (paratyphoid) fever. While today a potentially lethal infection of humans that occurs in Africa and Asia, early 20th century observations in Eastern Europe suggest it may once have
Achtman, Mark, Alikhan, Nabil-Fareed, Casjens, Sherwood, Christophersen, Axel, Dien, Alicia Tran, Duchêne, Sebastián, Fotakis, Anna K., Gilbert, M. Thomas P., Hamre, Stian S., Ho, Simon, Langridge, Gemma, Lundstrøm, Inge, Nair, Satheesh, Quince, Christopher, Sergeant, Martin J., Stenøien, Hans K., Thomson, Nicholas R., Weill, François-Xavier, Zhou, Zhemin   +18 more
core  

Comparative analysis of the characteristics and trends of adverse drug reaction reports from patients in Japan and the Japanese Adverse Drug Event Report database

British Journal of Clinical Pharmacology, EarlyView.
Aims Spontaneous reporting of adverse drug reactions (ADR) after a product has reached the market is essential for drug safety. This study analysed patient ADR reports and compared them with reports from the Japanese Adverse Drug Event Report (JADER) database to identify differences and trends.
Masami Tsuchiya, Ryohkan Funakoshi, Koichi Masuyama, Nariyasu Mano, Satoko Hori, Taku Obara   +5 more
wiley   +1 more source

The Infectivity of Enteric Fever [PDF]

, 1898
Elizabeth Saunders
openalex   +1 more source

Emerging Challenges and Opportunities in Infectious Disease Epidemiology. [PDF]

, 2019
Much of the intellectual tradition of modern epidemiology stems from efforts to understand and combat chronic diseases persisting through the 20th century epidemiologic transition of countries such as the United States and United Kingdom.
Lewnard, Joseph A, Reingold, Arthur L
core  

Pharmacokinetics of teicoplanin in paediatric patients—A systematic review of current literature

British Journal of Clinical Pharmacology, EarlyView.
Background and Objective Teicoplanin is commonly used in children to treat gram‐positive infections and is sometimes used off‐label prophylactically in surgical or paediatric oncology settings. The pharmacokinetics (PK) of teicoplanin in children exhibit considerable variability, such as in critically ill children or those with renal impairment.
Noa E. Wijnen, Daan J. Touw, Kim Klein, Gertjan J. L. Kaspers, Paola Mian   +4 more
wiley   +1 more source