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A library of easily synthesizable CAPE analogs was screened in silico against the dengue virus envelope protein. Compound LQM778 showed stable binding and promising inhibitory potential. This study highlights LQM778 as a candidate for future in vitro validation and structural optimization toward accessible antiviral agents against dengue.
Luis Alfonso Cárdenas‐Granados+9 more
wiley +1 more source
Abstract Unsustainable hunting practices can alter population dynamics, driving biodiversity declines, which leads to ‘empty forests’. Understanding hunting behaviour, including motivations for hunting and relationships with market drivers, and access to hunting grounds are important to develop affirmative policies to stem biodiversity loss.
Natasha L. M. Mannion+6 more
wiley +1 more source
ABSTRACT Background Food safety practices are widely recommended for pediatric patients with cancer or undergoing hematopoietic stem cell transplantation (HCT) to mitigate foodborne infectious risks. However, specific measures, such as the neutropenic diet (ND) or low‐microbial diet, lack robust evidence and are inconsistently implemented across ...
Davide Leardini+28 more
wiley +1 more source
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The Indian Journal of Pediatrics, 2016
Enteric fever is an important public-health problem in India. The clinical presentation of typhoid fever is very variable, ranging from fever with little other morbidities to marked toxemia and associated multisystem complications. Fever is present in majority of patients (>90 %) irrespective of their age group. Mortality is higher in younger children.
Praveen Kumar, R. R. Kumar
openaire +3 more sources
Enteric fever is an important public-health problem in India. The clinical presentation of typhoid fever is very variable, ranging from fever with little other morbidities to marked toxemia and associated multisystem complications. Fever is present in majority of patients (>90 %) irrespective of their age group. Mortality is higher in younger children.
Praveen Kumar, R. R. Kumar
openaire +3 more sources