Results 211 to 220 of about 2,027,320 (311)

Microneedle Patch for In Situ Neutrophil Monitoring

open access: yesAdvanced Science, EarlyView.
An in situ chromogenic microneedle patch that achieves daily blood neutrophil monitoring without vascular invasion or laboratory apparatus is developed. The detection ability is well demonstrated in a chemotherapy‐induced neutropenic rat model and can be read out using a mobile phone application.
Ziyi Lu   +26 more
wiley   +1 more source

Hosts and Commensal Bacteria Synergistically Antagonize Opportunistic Pathogens at the Single‐Cell Resolution

open access: yesAdvanced Science, EarlyView.
In the tripartite‐species model, Drosophila larvae stimulate lactate production through excreting digestion enzymes. S. marcescens population senses a cue of lactate and tends to diverge into virulent and reduced virulence subclusters with remarkable heterogeneity to metabolize carbon metabolism and counter colonization resistance, giving a fitness ...
Sheng Zhang   +10 more
wiley   +1 more source

Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery

open access: yesAdvanced Science, EarlyView.
A high‐strength pH‐responsive hydrogel‐forming microneedle integrates gradient solvent replacement to enhance the mechanical properties of the acrylonitrile‐acrylic acid copolymer network, ensuring robust transdermal penetration and long‐term drug release.
Hui Li   +12 more
wiley   +1 more source

The FGF13‐Caveolin‐1 Axis: A Key Player in the Pathogenesis of Doxorubicin‐ and D‐Galactose‐Induced Premature Cardiac Aging

open access: yesAdvanced Science, EarlyView.
The FGF13 level is significantly downregulated in premature aging murine hearts subject to D‐galactose and Doxorubicin. FGF13 overexpression and deficiency exacerbated and alleviated Doxorubicin/D‐galactose‐induced myocardial aging characteristics and functional impairment, respectively.
Enzhao Shen   +15 more
wiley   +1 more source

Radical‐Polar Crossover Bicyclization Enables a Modular Synthesis of Saturated Bicyclic Amines

open access: yesAdvanced Science, EarlyView.
Herein, we report the successful realization of a radical‐polar crossover bicyclization reaction from easily available cyclopropylamines and substituted alkenes through photoredox catalysis. This approach introduces an innovative methodology for the de novo synthesis of a diverse collection of 4/5‐, 5/5‐, 6/5‐,7/5‐ and 5/6‐fused saturated bicyclic ...
Dewei Feng   +4 more
wiley   +1 more source

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