Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy
Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang+3 more
wiley +1 more source
The 'side effects' of digitalization: A study on role overload and job burnout of employees. [PDF]
Zhang Q, Dai W, Chen J, Gu Y, Zhao Y.
europepmc +1 more source
The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu+17 more
wiley +1 more source
Different paths, same destination, yet diverse effects: Antecedent configurations and performance implications of digital transformation in pharmaceutical manufacturing enterprises--Evidence from Chinese listed companies. [PDF]
Shi B, Mou C, Zhang Y, Cui T.
europepmc +1 more source
Memristive In‐Memory Object Detection with 128 Mb C‐Doped Ge2Sb2Te5 PCM Chip
A memristive in‐memory object detection system is presented for edge computing based on a 128 Mb phase change memory chip (40 nm, 99.99999 % yield) enabling in‐memory vector‐matrix multiplication and max computation. A novel mixed‐precision weight mapping reduces analog‐to‐digital‐converter energy by 22.3×.
Chenchen Xie+13 more
wiley +1 more source
How does digital transformation affect corporate sustainability performance? Evidence from listed energy companies in China. [PDF]
Guo L, Chen F, Chen L.
europepmc +1 more source
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu+7 more
wiley +1 more source
The role of Kaizen in the effectiveness of Amhara metal industry and machine technology development enterprise in Ethiopia, as perceived by the employees. [PDF]
Gebremeskel MM.
europepmc +1 more source