Results 71 to 80 of about 1,359 (252)

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Un Caso de Estudio para la Adopción de un Modelo de Trazabilidad de Requisitos en el Sector Energético

Lámpsakos, 2014
Es fundamental para un desarrollo de software, mejorar el proceso relacionado con los requisitos, los aspectos que facilitan una mejora, es contar con la posibilidad de realizar trazados a los requisitos a lo largo del ciclo de vida de un sistema.
Lina María Montoya-Suárez, Juan Carlos Monsalve-Gómez, Jorge Mauricio Sepúlveda-Castaño   +2 more
doaj  

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Sistema para la gestión de nomencladores System for managing nomenclatures

Revista Cubana de Ciencias Informáticas, 2012
A partir de la necesidad de gestionar información común y poco variable en el tiempo se crea el Sistema Nomenclador del sistema Balance y Planificación de Insumos Médicos (alas BAP), con el objetivo de centralizar la gestión de los nomencladores.
José Mojena Alpizar, Renán Vázquez Moreno   +1 more
doaj  

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

System for managing nomenclatures Sistema para la gestión de nomencladores

Revista Cubana de Ciencias Informáticas, 2012
From the need to manage common information and relatively constant over time creates the Nomenclature System Evaluation and Planning System of Medical Supplies (wings BAP), in order to centralize the management of nomenclatures. This module was deficient
Renán Vázquez Moreno, José Mojena Alpizar   +1 more
doaj  

SISTEMA PARA LA PLANIFICACIÓN QUIRURGICA ORTOPÉDICA EN EXTREMIDADES

Revista Cubana de Informática Médica, 2015
Los distintos procedimientos quirúrgicos en ortopedia presentan un elevado nivel de complejidad y requieren de una adecuada planificación que incremente las probabilidades de éxito de los mismos.
Ing. Maria de Jesús Cartelle Cruz, Ing. Yicel Rivera Suárez, Ing. Luis Mariano Reyna Soler   +2 more
doaj   +2 more sources