Results 71 to 80 of about 355,423 (297)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Using Ontologies for Enterprise Architecture Integration and Analysis

Complex Systems Informatics and Modeling Quarterly, 2014
Enterprise architecture facilitates the alignment between different domains, such as business, applications and information technology. These domains must be described with description languages that best address the concerns of its stakeholders. However,
Gonçalo Antunes, Marzieh Bakhshandeh, Rudolf Mayer, José Borbinha, Artur Caetano   +4 more
doaj   +1 more source

Extended enterprise architecture with the FADEE. [PDF]

Business-to-Business integration (B2Bi) is considered to be not merely an IT-issue, but also a business problem. This paper draws attention to the challenges companies within an Extended Enterprise are confronted with when integrating their systems.
Cumps, Bjorn, Goethals, Frank, Lemahieu, Wilfried, Snoeck, Monique, Vandenbulcke, Jacques   +4 more
core  

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

An Affordance Perspective on Generative AI in Enterprise Architecture

IEEE Access
Generative artificial intelligence (GenAI) has emerged as a transformative technology capable of creating novel content across multiple formats. Its rapid advancement fuels innovations and implications for various fields, including the unexplored domain ...
Leonardo Banh, Tuan Khang Tran, Gero Strobel   +2 more
doaj   +1 more source

Enterprise Architecture Planning (Eap) Si/ti Menggunakan Togaf Adm pada Dinas Cipta Karya, Tata Ruang dan Kebersihan Kabupaten Kubu Raya [PDF]

, 2015
Department of copyrighted work, spatial and hygiene district of Kubu Raya experiencing operational constraints due to budget, facilities and human resources.
Irmayani, W. (windi)
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Perancangan Enterprise Architecture Proses Pelatihan Kerja [PDF]

, 2014
One of the components of enterprise architecture (EA) is information architecture (IA), which has three elements, those are people, process, and technology.
Gondokary, Y. S. (Yudi), Herawati, D. (Dewi)   +1 more
core  

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

MODEL ARSITEKTUR ENTERPRISE MENGGUNAKAN ENTERPRISE ARCHITECTURE PLANNING (EAP)

JSiI (Jurnal Sistem Informasi), 2019
Abstrak - Akademi Abdi Nusa pangkalpinang  merupakan sistem informasi yang bergerak dibidang pendidikan kesehatan. Dengan adanya sistem interprise ini maka akan mendukung perencanaan sistem informasi yang baik dan teratur.
Marini Marini, Sarwindah Sarwindah
doaj   +1 more source