Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Joint Registration and Conformal Prediction for Partially Observed Functional Data. [PDF]
Wang F, Kurtek S, Zhang Y.
europepmc +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The Statistical-Mechanical Meaning of the Wave Function of Quantum Mechanics. [PDF]
Robledo A.
europepmc +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
A Low-Cost Two-Dimensional Scalable Active Receive Phased Array with 8 Simultaneously Reconfigurable Beams. [PDF]
Zhang H +6 more
europepmc +1 more source
Spatial pattern of herbaceous seed dispersal by ungulates in grasslands of Doñana, SW Spain. [PDF]
Leiva MJ, Fedriani JM.
europepmc +1 more source
Simple input-output dependencies explain neuronal activity. [PDF]
Lynn CW.
europepmc +1 more source
Learning Latent Representations to Bridge Coarse-Grained and Atomistic Resolutions in Polymer Simulations. [PDF]
Desai S +5 more
europepmc +1 more source
Two-year longitudinal neuropsychological monitoring after unilateral and staged bilateral subthalamic nucleus deep brain stimulation. [PDF]
Iwański S +3 more
europepmc +1 more source

