Results 161 to 170 of about 3,381,515 (303)

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

open access: yesFEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman   +3 more
wiley   +1 more source

Radial solutions of singular nonlinear biharmonic equations and applications to conformal geometry

open access: yesElectronic Journal of Differential Equations, 2003
Positive entire solutions of the singular biharmonic equation $Delta^2 u + u^{-q}=0$ in $mathbb{R}^n$ with $q>1$ and $ngeq 3$ are considered. We prove that there are infinitely many radial entire solutions with different growth rates close to quadratic ...
P. J. McKenna, Wolfgang Reichel
doaj  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Entire solutions for a mono-stable delay population model in a 2D lattice strip

open access: yesElectronic Journal of Differential Equations, 2014
This article concerns the entire solutions of a mono-stable age-structured population model in a 2D lattice strip. In a previous publication, we established the existence of entire solutions related to traveling wave solutions with speeds larger than ...
Hai-Qin Zhao, San-Yang Liu
doaj  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Existence of entire solutions for non-local delayed lattice differential equations

open access: yesElectronic Journal of Differential Equations, 2013
In this article we study entire solutions for a non-local delayed lattice differential equation with monostable nonlinearity. First, based on a concavity assumption of the birth function, we establish a comparison theorem.
Shi-Liang Wu, San-Yang Liu
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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