Results 211 to 220 of about 434,263 (264)

Development and Verification of Crack-Enriched Elements Based on XFEM. [PDF]

Materials (Basel)
Shi Y, Chen L, Zhao P, Huo J, Shi L.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Protocol for using the multi-cellular analysis toolbox in ImageJ for single-cell calcium imaging analysis. [PDF]

STAR Protoc
Hageter J, Horstick E.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of <i>Bacillus subtilis</i> and <i>Paenibacillus polymyxa</i> on the Compressive Strength and Self-Healing of Type IP Concrete. [PDF]

Materials (Basel)
Rivas Torres BR, Mendoza Tejada OG, Francisco Gamarra Tuco R, Ita-Balta Y, Farfán-Delgado F, Manrique-Sam C.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Stereospecific Antifungal Activity of Strigolactone Analogues Against <i>Botrytis cinerea</i> and <i>Sclerotinia sclerotiorum</i>. [PDF]

J Fungi (Basel)
Huang P, Yao R, Chen L.
europepmc   +1 more source

Biomechanical Analysis of Antibiotic-Treated Tendon Grafts With Digital Image Correlation: A Comparison Between Vancomycin, Gentamycin, and Tobramycin Soaking Techniques. [PDF]

Orthop J Sports Med
Burton M, Pisini D, Flanigan E, Seidt J, Piscitani F, Magnussen RA, Kaeding CC, Barker T, Flanigan DC.   +8 more
europepmc   +1 more source

Beyond reproduction: The ovary as a systemic regulator of female health and aging. [PDF]

PLoS Biol
Garrison JL.
europepmc   +1 more source