Results 241 to 250 of about 421,523 (312)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Revitalizing actinobacteria research: an urgent response to the antimicrobial resistance crisis. [PDF]

Nat Prod Bioprospect
Cibulski SP, Rodrigues-Junior VDS.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Entire solutions to Fermat-type difference and partial differential-difference equations in C^n

Electronic Journal of Differential Equations
Hong Yan Xu, Goutam Haldar
doaj  

Globalizing digital immunization systems for the sustainable development goals: a perspective. [PDF]

Front Digit Health
Ibeneme S, Blaschke S, Aung KD, Droti B, Gustiana R, Kipruto H, Rodriques B.   +6 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Fourier Approximation of magMEMS Oscillations: Neural Network Space Handling. [PDF]

Micromachines (Basel)
Skrzypacz P, Bolatov A, Dziedzic A, Ellis G, Tangirbergen K, Pruchnik B, Putek P.   +6 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

What is next for Hematology, Hemotherapy and Cell Therapy? A message and an invitation from incoming editors. [PDF]

Hematol Transfus Cell Ther
De Paula EV, Dinardo CL.
europepmc   +1 more source

Existence and stability properties of entire solutions to the polyharmonic equation $(-\Delta)^m u=e^u$ for any $m\ge 1$ [PDF]

, 2014
Alberto Farina, Alberto Ferrero
openalex