Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Academia loses its grip on digital health solutions as innovation in artificial intelligence shifts towards industry. [PDF]
NPJ Digit MedHijaz BA +3 more
europepmc +1 more source
NeuberNet: a neural operator solving elastic-plastic partial differential equations at V-notches from low-fidelity elastic simulations. [PDF]
Commun EngGrossi T, Beghini M, Benedetti M.
europepmc +1 more source
The All-of-Society Approach to Evidence-informed Policymaking in the Implementation of the Universal Healthcare Act of 2019. [PDF]
Acta Med PhilippTiangco BJ.
europepmc +1 more source
Conformal Curved-Electrode Sensor with High-Frequency Optimization for Distributed Conductivity Monitoring in Shipboard Desalination Pipelines. [PDF]
Sensors (Basel)Wang W +6 more
europepmc +1 more source
Transfer-learning on federated observational healthcare data for prediction models using Bayesian sparse logistic regression with informed priors. [PDF]
J Am Med Inform AssocLi KM +4 more
europepmc +1 more source
Entire solutions of the allen-cahn equation and complete embedded minimal surfaces
, 2009 Manuel del Pino +2 more
openalex +1 more source