Results 161 to 170 of about 1,940 (229)

A Model of Strategic Sustainable Investment

open access: yesMathematical Finance, EarlyView.
ABSTRACT We study a problem of optimal irreversible investment and emission reduction formulated as a nonzero‐sum dynamic game between an investor with environmental preferences and a firm. The game is set in continuous‐time on an infinite‐time horizon.
Tiziano De Angelis   +2 more
wiley   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

open access: yesMolecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan   +2 more
wiley   +1 more source

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

open access: yesMolecular Microbiology, EarlyView.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh   +2 more
wiley   +1 more source

Anti-Inflammatory and Pro-Healing Effects of Human Plasma-Derived Exosomes in a Murine Wound Model. [PDF]

open access: yesJ Cosmet Dermatol
Yang H   +8 more
europepmc   +1 more source

Impaired hematopoiesis affects apheresis and CAR T‐cell product composition and treatment response

open access: yesTransfusion, EarlyView.
Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of hematologic malignancies, but its success depends on obtaining sufficient CD3+ T‐cell yields during leukapheresis. This can be difficult in heavily pretreated patients, who often show leukopenia and reduced T‐cell fitness.
Hanna Kuhn   +14 more
wiley   +1 more source

Cerebral oxygenation and skeletal muscle responses to time trial, maximal oxygen uptake and time to exhaustion exercise

open access: yesExperimental Physiology, EarlyView.
Abstract This study investigated cerebral and neuromuscular responses to three exercise models: time trial (TT), maximal oxygen uptake (V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}{\mathrm{max}}}}$) and time to exhaustion (TTE). Fourteen participants completed the tests in the following order: V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}{\mathrm{max}}}}$, TT and ...
Caroline V. Robertson   +3 more
wiley   +1 more source

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