Results 191 to 200 of about 1,940 (229)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

open access: yesMedicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur   +6 more
wiley   +1 more source

Stability of a Fully Discrete Local Discontinuous Galerkin Method for the Generalized Benjamin–Ono Equation

open access: yesNumerical Methods for Partial Differential Equations, Volume 42, Issue 4, July 2026.
ABSTRACT The main purpose of this paper is to design a fully discrete local discontinuous Galerkin (LDG) scheme for the generalized Benjamin–Ono equation. First, we prove the L2$$ {L}^2 $$‐stability for the proposed semi‐discrete LDG scheme and obtained a suboptimal order of convergence for power nonlinear flux.
Mukul Dwivedi, Tanmay Sarkar
wiley   +1 more source

On the Choice of Optimization Norm for Anderson Acceleration of the Picard Iteration for Navier–Stokes Equations

open access: yesNumerical Methods for Partial Differential Equations, Volume 42, Issue 4, July 2026.
ABSTRACT While recent Anderson acceleration (AA) convergence theory [Pollock et al., IMA Num. An., 2021] requires that the AA optimization norm match the Hilbert space norm associated with the fixed point operator, in implementations the ℓ2$$ {\ell}^2 $$ norm is the most common choice. So far there is little research done regarding this discrepancy. To
Elizabeth Hawkins, Leo G. Rebholz
wiley   +1 more source

Dental Biofilm–Induced Gingivitis in Children and Adolescents Without Known Systemic Involvement: A Systematic Review

open access: yesJournal of Clinical Periodontology, Volume 53, Issue 7, Page 1226-1252, July 2026.
ABSTRACT Aim To synthesize evidence on gingival diseases and conditions in children and adolescents (< 18 years) without known systemic disorder involvement, focusing on their distribution, aetiology, diagnosis, management and oral health–related quality of life (OHRQoL).
Georgios Tsilingaridis   +4 more
wiley   +1 more source

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

open access: yesThe FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani   +16 more
wiley   +1 more source

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