Results 171 to 180 of about 73,004 (270)

Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract

Aging Cell, Volume 25, Issue 5, May 2026.
Telomere shortening occurs with age in the respiratory epithelium, but telomere dysfunction‐induced foci (TIF) accumulate only late in life. In contrast, proteostasis decline emerges earlier and correlates with functional impairment, suggesting it may be a primary driver of cellular senescence during physiological aging.
Céline Coquette, Kamar Bouchoucha, Manon Mahieu, Stijn E. Verleden, Axelle Loriot, Kevin Norris, Duncan M. Baird, Amélie Derumier, Delphine Hoton, Laurens De Sadeleer, Arno Vanstapel, Bart M. Vanaudenaerde, Maëlle de Ville de Goyet, Bénédicte Brichard, Antoine Froidure, Wim Wuyts, Jan Van Slambrouck, Laurens J. Ceulemans, William Trigaux, Caroline Huart, Anabelle Decottignies   +20 more
wiley   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, Volume 36, Issue 3, May 2026.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease. [PDF]

Brain Commun
Tan JXM, Kang MS, Yeh YH, Bezgin G, Lussier FZ, Hong SJ, Isen J, Rahmouni N, Vitali P, Montembeault M, Klostranec JM, Macedo AC, Chan T, McLaurin J, Swardfager W, Bernhardt BC, Stefanovic B, Soucy JP, Gauthier S, Black SE, Rosa-Neto P, Ottoy J, Goubran M.   +22 more
europepmc   +1 more source

The Development of Temporal Memory for Complex Events

Developmental Science, Volume 29, Issue 3, May 2026.
ABSTRACT Remembering when past events occurred is a key component of episodic memory, yet its developmental trajectory remains only partially understood. This study examined how children aged 6 and 10, compared to young adults, recall the timing of events embedded in an 11‐min cartoon.
Matteo Frisoni, Tiziana Pedale, Michele Capurso, Valerio Santangelo, Carlo Sestieri   +4 more
wiley   +1 more source

Sex modulates the ApoE ε4 effect on brain tau deposition measured by 18F-AV-1451 PET in individuals with mild cognitive impairment [PDF]

, 2019
Benzinger, Tammie L.S., Duy, Phan Q., Goyal, Manu S., Liu, Min, Lu, Jie, Paranjpe, Manish D., Wang, Rongfu, Zhou, Xin, Zhou, Yun   +8 more
core   +1 more source

Oxytocin Neuron‐Specific CAPS2 Deficiency in Mice Impairs Hippocampal Plasticity and Long‐Term Memory Through Reduced ERK Phosphorylation in the Ventral hippocampus

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
The CAPS2 cKO mouse, characterized by reduced oxytocin release, exhibits impaired cognitive function and disrupted hippocampal long‐term potentiation. ABSTRACT Oxytocin (OXT), a neuropeptide produced in the paraventricular nucleus (PVN) of the hypothalamus, regulates social behaviour, stress responses, and memory. Our previous studies demonstrated that
Wakana Nagano, Junpei Takahashi, Tsugumi Yamauchi, Daisuke Yamada, Yoshitake Sano, Teiichi Furuichi, Akiyoshi Saitoh   +6 more
wiley   +1 more source

Differential Encoding of Odor and Place in the Mouse Piriform and Entorhinal Cortex. [PDF]

eNeuro
Mena W, Baker K, Rubin A, Kohli S, Yoo Y, Bathellier B, Ziv Y, Fleischmann A, Rezaei-Mazinani S.   +8 more
europepmc   +1 more source

Quantitative 18F-AV1451 brain tau PET imaging in cognitively normal older adults, mild cognitive impairment, and Alzheimer\u27s disease patients [PDF]

, 2019
Alzheimer\u27s Disease Neuroimaging Initiative,, Ha, Lingxia, Liu, Min, Zhao, Qian, Zhou, Yun   +4 more
core   +1 more source

Insulin Receptor Isoform Pattern in Aged Normal and Alzheimer's Human Cortex

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
In this study we asked (A) which antibodies accurately detect insulin receptors in human brain? Our data demonstrate that the three antibodies we have characterised work well but there is a hierarchy with 250 724 working well, PA5‐27334 working better and NBP‐12793 working best.
Catherine Webb‐Robinson, Helen Murray, Clinton P. Turner, Thulani Palpagama, Richard L. M. Faull, Maurice A. Curtis   +5 more
wiley   +1 more source

Connectivity of the Superior Temporal Polysensory Area With the Presubiculum, Parasubiculum, Entorhinal Cortex, and Claustrum-Endopiriform Complex in the Common Marmoset (Callithrix jacchus). [PDF]

J Comp Neurol
Honda Y, Moriya-Ito K, Hashimoto N, Kobayashi Y.   +3 more
europepmc   +1 more source