Entrectinib-related Myocarditis Causing a Triangular QRS-ST-T Waveform Electrocardiographic Pattern: A Case Report [PDF]
Clinical Practice and Cases in Emergency MedicineIntroduction: Entrectinib is a kinase inhibitor used in ROS1-positive non-small cell lung carcinoma. Cardiovascular toxicity is rare, with only one prior report of myocarditis related to entrectinib use.
William Dean +3 more
doaj +3 more sources
Long-Term Efficacy and Safety of Entrectinib in ROS1 Fusion–Positive NSCLC [PDF]
JTO Clinical and Research Reports, 2022 Introduction: Entrectinib is an approved tyrosine kinase inhibitor (TKI) for ROS1 fusion–positive NSCLC. An updated integrated analysis of entrectinib from the ALKA-372-001, STARTRK-1, and STARTRK-2 trials is presented, with substantially longer follow ...
Robert C Doebele +2 more
exaly +7 more sources
Entrectinib for the treatment of metastatic NSCLC: safety and efficacy [PDF]
Expert Review of Anticancer Therapy, 2020 Introduction: Gene fusions are strong driver alterations in various cancers, increasingly diagnosed with multiple testing techniques. ROS1 fusions can be found in 1-2% of non-small cell lung cancer (NSCLC) and several tyrosine kinase inhibitors (TKIs) have been tested in this oncogene-driven disease.
Federica Maria Tôsi +2 more
exaly +5 more sources
Impact of Long‐Term Structured Exercise on Body Composition in an NTRK Fusion‐Positive NSCLC Patient Treated With Entrectinib [PDF]
Thoracic CancerEntrectinib, a first‐generation TRK inhibitor, is effective in NTRK fusion‐positive non‐small cell lung cancer (NSCLC) but commonly induces significant weight gain.
Alice Avancini +14 more
doaj +3 more sources
Entrectinib results in ventricular tachycardia and Brugada phenocopy through inhibition of sodium current [PDF]
Cardio-OncologyBackground Entrectinib is a tropomyosin receptor kinase (TrK) inhibitor currently approved for the treatment of ROS1-positive non-small cell lung cancer (NSCLC) and neurotrophic tyrosine receptor kinase (NTRK) gene fusion-positive solid tumors.
Matthew R. Fleming +9 more
doaj +2 more sources
Case Report: Tyrosine kinase inhibitors in ROS1-rearranged and granulocyte colony-stimulating factor-producing lung squamous cell carcinoma [PDF]
Frontiers in OncologyBackgroundc-ros oncogene 1 (ROS1) fusions occur in less than 0.2% of lung squamous cell carcinomas (SqCCs). Concurrent production of granulocyte colony-stimulating factor (G-CSF) induces marked leukocytosis and is associated with aggressive tumor ...
Ruijie Li +3 more
doaj +2 more sources
Radioiodine-Refractory Differentiated Thyroid Cancer: Definition, Molecular Mechanisms, and Advances in Precision Therapy. [PDF]
Cancer InnovRadioiodine‐refractory differentiated thyroid cancer (RAIR‐DTC) management now spans selective kinase inhibitors, MAPK‐pathway redifferentiation, VEGFR multikinase TKIs, and biomarker‐driven immunotherapy. We propose a three‐axis decision framework integrating molecular driver, evidence level, and patient dimension to guide individualized treatment ...
Li Y, He Z.
europepmc +2 more sources
RBPMS::NTRK3-rearranged sacral malignant spindle cell tumor in neurofibromatosis diagnosed by RNA sequencing: a case report and literature review [PDF]
Frontiers in MedicineMalignant spindle cell tumors arising in patients with neurofibromatosis are diagnostically challenging because malignant peripheral nerve sheath tumor (MPNST) and emerging NTRK-rearranged mesenchymal neoplasms may show overlapping clinical, histological,
Chaopeng Chen +5 more
doaj +2 more sources
Refractory ventricular tachyarrhythmias following entrectinib initiation in metastatic lung adenocarcinoma: a case report [PDF]
Journal of Medical Case ReportsBackground Entrectinib is a targeted therapy that has been approved for the treatment of ROS1-positive non-small cell lung cancer. However, this therapy is associated with known but rare cardiotoxic risks.
Lili Tang +3 more
doaj +2 more sources
Frontiers in Microbiology, 2023 Over the last few decades, Staphylococcus aureus infection remain a major medical challenge and health concern worldwide. Biofilm formation and antibiotic resistance caused by S.
Shanghong Liu +11 more
doaj +1 more source