Results 61 to 70 of about 965,763 (309)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Prior Experience and Export Performance: The Missing Link of Global Vision [PDF]

, 2020
Despite the scholarly interest in the prior experience of entrepreneurs expressed by the field of International Entrepreneurship, empirical investigation linking prior experience with international performance leads to inconclusive and conflicting ...
Faroque, Anisur R, Kuivalainen, Olli, Mostafiz, Md Imtiaz, Sundqvist, Sanna   +3 more
core  

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Factors influencing the entrepreneurial engagement of opportunity and necessity entrepreneurs

Eurasian Business Review, 2016
The scholarly literature often distinguishes between so-called opportunity and necessity entrepreneurship and between “pull” and “push” motivations. Despite the pervasive use of this terminology, empirical analyses are mostly based on a single country ...
Peter van der Zwan, R. Thurik, I. Verheul, J. Hessels   +3 more
semanticscholar   +1 more source

A Perspective on the Applications of Triphasic Gas Storage in Electrochemical Systems

Advanced Science, EarlyView.
Gas storage in microporous materials positioned locally at an electrode or electrocatalyst surface enhances electrochemical processes. Abstract Microporous materials store gases under dry conditions (e.g., hydrogen or oxygen via physisorption), but in some cases microporous materials also show triphasic (e.g., in a solid|gas|liquid system) gas storage ...
Zhongkai Li, Corin T. Scott, Taku Suzuki‐Osborne, John P. Lowe, Dominic Taylor, Mariolino Carta, Neil B. McKeown, Andrew D. Burrows, Lucia H. Mascaro, Frank Marken   +9 more
wiley   +1 more source

All Seats Taken? Hyperlocal Online Media in Strong Print Newspaper Surroundings

Nordicom Review, 2019
This article present data from a new mapping of Norwegian online hyperlocals, defined as local online news sites that are indigenous to the web. From an understanding of local news markets as organised social fields with great barriers to entry, we ...
Halvorsen Lars Julius, Bjerke Paul
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A gender perspective on entrepreneurial leadership:female leaders in Kazakhstan [PDF]

, 2017
The paper proposes a conceptual model to understand female entrepreneurial leadership through an exploration of the perceptions and experiences of women entrepreneurs within their leadership roles.
Ahl, Ahl, Aidis, Al Dajani, Babalola, Bandura, Baron, Baron, Bass, Bass, Baum, Baum, Bendassolli, Bennett, Bernard, Bhuiyan, Bjerke, Boal, Bourne, Browne, Bruin, Bruni, Brush, Campbell, Chandler, Charmaz, Choi, Cogliser, Corbett, Daily, Datta, Davis, Den Hartog, Drucker, Dzisi, Eagly, Eagly, Eagly, Eagly, Eagly, Eddleston, Ehrlich, Elliott, Ensley, Erikson, Fairhurst, Foss, Franco, Gaglio, Garcia, Gilligan, Grant, Guest, Gundry, Hargittai, Heckathorn, Helgesen, House, Hughes, Hutchinson, Idris, Ireland, Izyumov, Jamali, James, Jennings, Jensen, Kakabadse, Kakabadse, Kakabadse, Karataş-Özkan, Karataş-Özkan, Karataş-Özkan, Katz, Kennedy, Kirkwood, Kobia, Kolb, Kotter, Kreiser, Kroeck, Kuratko, Lee-Gosselin, Leitch, Lewis, Lipman-Blumen, Lord, Lowe, Luthans, Maak, Matzler, McKie, Miles, Mirchandani, Moore, Mumford, Mumford, Nicolopoulou, Osborn, Patton, Pech, Phillips, Pless, Renko, Rosener, Saldana, Schacter, Schein, Schumpeter, Scott, Sevä, Shabbir, Shane, Shinnar, Smirnova, Stewart, Strauss, Tatli, Teal, Thomas, Thornberry, Timmons, Tlaiss, Van Emmerik, Wee, Werner, Youssef-Morgan, Zhu, Özbilgin   +128 more
core   +5 more sources

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

The Impact of Business Incubators on the Performance of the Entrepreneurial Ecosystem [PDF]

Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics
More and more researchers are addressing in their work the importance of the interaction between entrepreneurship and sustainability in dynamic business environments.
Oana Pricopoaia, Stefan Adrian Susanu, Nicoleta Cristache, Irina Olimpia Susanu   +3 more
doaj   +1 more source